A Critical Review of Existing Evidence on the Relationships between Sex Steroid Hormone Levels in Benign and Malignant Breast Tissue and Blood

Ted Auden^*
*Correspondence: Ted Auden, Departments of Obstetrics and Gynecology, University of Sydney, Austria, Email:

Introduction

Certain sex steroids have been firmly established as being significantly associated with risk in large prospective collections of plasma samples from women prior to the development of breast cancer, according to a study of large prospective collections of plasma samples from women prior to the development of breast cancer. The strongest connections were discovered in postmenopausal women, who have far less within-person variability of most hormones, but some favourable associations were also discovered in premenopausal women. The strongest associations with risk are found in plasma oestrogens, which are bolstered by measuring or calculating the proportion of estradiol that circulates free of sex hormone binding globulin [1].

Description

This is in line with the fact that this is the most active group. The associations have been claimed to explain nearly the entire link between breast cancer and BMI in postmenopausal women; this is likely due to the presence of non-ovarian estrogenic production in subcutaneous fat. Because of these strong links, plasma and urine estrogenic levels are now being employed as intermediate end-points in the hunt for genes that influence breast cancer risk through their function in steroid disposal. The 'correction' for oestrogen levels weakens but does not abolish the connection between plasma testosterone levels and breast cancer risk [2]. This has been interpreted as evidence that local oestrogen production has a role in the aetiology of breast cancer. Given that plasma steroid levels do not directly correspond with mammographic density, which is highly associated with risk, there is potential to integrate the two parameters in determining breast cancer risk, but the lack of appropriate oestrogen assays is a big roadblock. Plasma oestrogens have been observed to correlate with gene expression of estrogen-dependent genes in established breast cancer, and the expression of these genes varies throughout the menstrual cycle in premenopausal women that some premenopausal women's breast tumours retreated in response to oophorectomy, and this was the first of many observations that link reproductive physiology to breast cancer risk, treatment, and prevention. The efficacy of endocrine drugs in the adjuvant setting is based on the substantial dependence of many breast tumours on oestrogen for their growth, which contributes to a significant improvement in prognosis [3].

This review will look at the factors that impact circulating sex steroids, with a focus on estradiol levels, in both premenopausal and postmenopausal women, as well as the effects of the hormonal environment on breast cancer development, therapy, and prognosis. The technical constraints of the methodology used to quantify steroids particularly estradiol, and consideration premenopausal women, oestrogen is produced in the granulosa cells of the ovary, which limits some of the scientific significance of studies in this area [4]. Testosterone and androstenedione are converted by the aromatase enzyme. Estradiol and estrone are estradiol and estrone, respectively. \Aromatase is also found in peripheral tissues like adipose tissue and skin, though at lesser levels, where its activity is regulated by other factors like, prostaglandin, and glucocorticoids [5]. After menopause, as the ovary's oestrogen and progesterone output drops, the peripheral tissues continue to produce circulating estradiol. In postmenopausal women, circulatory estradiol levels do not fluctuate significantly, remaining rather steady within an individual.

Conclusion

In comparison to those found in younger women, they are low. Although some studies have questioned the efficacy of using circulating estradiol measures as an end point in postmenopausal women, they claim that circulating oestrogens are only a limited reflection of tissue metabolism and that tissue levels should be examined to reflect exposure. In postmenopausal women, oestrogen levels in tissues such as the breast are higher than circulating levels. Recent evaluations show that this is not the case. Researchers have discovered that plasma oestrogens are an effective proxy for tissue levels in benign breast tissue due to the fast exchange between tissue and the extracellular matrix. Breast cancers have higher oestrogen levels than the surrounding tissue. Endogenous levels of sex steroids are connected to breast cancer risk and long-term tumour growth in postmenopausal women, and sex hormones promote breast cell proliferation and division. Hormone responsive breast cancer. The need for large sample sizes and variation between laboratories in the assessment of hormones are the two biggest issues with getting precise estimates of relative risks of breast cancer. The Endogenous Hormones and Breast Cancer Collaborative Group reviewed nine prospective risk studies and showed that every doubling of estradiol levels increased the relative risk by They discovered significant differences between laboratories, particularly for estradiol readings, and had to conduct a risk analysis.

References

1. Hankinson, Susan E., and A. Heather Eliassen. "Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer risk."  J Ster Biochemi Mole Bio 106 (2007): 24-30.

Indexed at, Google Scholar, Crossref

2. Liu, Ying, Nhi Nguyen and Graham A. Colditz. "Links between alcohol consumption and breast cancer: A look at the evidence." W Heal 11 (2015): 65-77.

Indexed at, Google Scholar, Crossref

3. Kakugawa, Yoichiro, Hiroshi Tada, Masaaki Kawaia and Takashi Suzuki, et al. "Associations of obesity and physical activity with serum and intratumoral sex steroid hormone levels among postmenopausal women with breast cancer: analysis of paired serum and tumor tissue samples." Bre Canc Rese Tre 162 (2017): 115-125.

Indexed at, Google Scholar, Crossref

4. Cook, Michael B., Frank Z. Stanczyk, Shannon N. Wood and Ruth M. Pfeiffer, et al. "Relationships between circulating and intraprostatic sex steroid hormone concentrations." Canc Epidemio Bio Prev 26 (2017): 1660-1666.

Indexed at, Google Scholar, Crossref

5. Gadducci, Angiolo, Nicoletta Biglia, Piero Sismondi and Andrea Riccardo Genazzani. "Breast cancer and sex steroids: Critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer." Gynec Endocrinol 20 (2005): 343-360.

Indexed at, Google Scholar, Crossref