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Platelet Activating Factor | Open Access Journals
Journal of Blood & Lymph

Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Platelet Activating Factor

Platelet Activating Factor is a powerful and functional mediator of inflammation that is produced by numerous cell types and tissues, particularly by leukocytes and have important role in the pathogenesis of inflammatory disorders and cardiovascular disease. It has been found to be produced by most immune cells, including eosinophils, basophils, mast cells, macrophages, and lymphocytes, as well as platelets and endothelial cells .Platelet-activating factor is synthesized in many different kinds of organisms such as mammals, plants, and unicellular eukaryotic and prokaryotic cells. In humans it is mainly synthesized in inflammatory-implicated cells such as macrophages, granulocytes, monocytes, platelets, and endothelial cells and also in the cells of many organs (e.g. kidney).

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Citations: 443

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