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Peripheral Blood Stem Cells Collection For Transplantation Online Journals | Open Access Journals
Journal of Blood & Lymph

Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Peripheral Blood Stem Cells Collection For Transplantation Online Journals

The main proposal that bone marrow transplantation may be conceivable happened in 1949 when Jacobson et al1 mentioned the objective fact that mice could endure in any case deadly absolute body illumination if the spleen was ensured by lead foil. A comparable radioprotective impact was checked whether bone marrow from one mouse was offered intravenously to an emanated beneficiary of the equivalent strain.2 By the mid‐1950s, a few research facilities had appeared, utilizing cytogenetic markers, that the radioprotective impact of bone marrow transplantation was because of the substitution of the harmed hematopoietic arrangement of the host with solid cells of benefactor origin.3 The potential clinical ramifications of these investigations were noted, and in 1959, the main endeavors to treat leukemia utilizing high‐dose chemoradiotherapy followed by syngeneic marrow transplantation were started by Dr. E. Donnell Thomas.4 Initial endeavors to apply transplantation outside the setting of indistinguishable twins were fruitless as a result of the absence of comprehension of the human histocompatibility framework.

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Citations: 443

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