This disorder can be caused by an injury or can occur spontaneously.
Typical symptoms include pain, limited range of motion of the affected joint, and, when the leg is affected, lameness. The diagnosis is based on the symptoms, the risk of osteonecrosis of the person and the results of x-rays and magnetic resonance imaging. Stopping smoking, stopping excessive alcohol consumption and reducing the use or decreasing the dose of corticosteroids reduce the risk of developing the disorder. Various surgical procedures can be performed if non-surgical measures (such as rest, physiotherapy and pain relievers) do not relieve symptoms.
In the United States, approximately 20,000 people develop osteonecrosis each year. The hip is most often affected, followed by the knee and shoulder. The wrist and ankle are less affected. Osteonecrosis generally does not affect the shoulder or other less commonly affected sites, unless the hip is also affected. However, osteonecrosis of the jaw (ONJ) is a disorder involving only the jaw bone.
As osteonecrosis progresses, more and more small fractures can occur, especially in the weight-bearing bones, such as the hip. As a result, the bone usually collapses weeks or months after the blood supply is stopped. Most often, the pain develops gradually when the bone begins to collapse. Sometimes, however, the pain can start suddenly and be linked to an increase in pressure that develops in and around the affected bone area. Regardless of the sudden intensity, the pain increases as the affected bone moves, and is usually lessened by rest. The person avoids moving the joint to minimize pain.
Short Communication: Journal of Bioanalysis & Biomedicine
Short Communication: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Research Article: Journal of Bioanalysis & Biomedicine
Posters & Accepted Abstracts: Pharmacoeconomics: Open Access
Posters & Accepted Abstracts: Pharmacoeconomics: Open Access
Scientific Tracks Abstracts: Pharmacoeconomics: Open Access
Scientific Tracks Abstracts: Pharmacoeconomics: Open Access
Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
Accepted Abstracts: Pharmaceutical Regulatory Affairs: Open Access
Scientific Tracks Abstracts: Pharmaceutical Regulatory Affairs: Open Access
Scientific Tracks Abstracts: Pharmaceutical Regulatory Affairs: Open Access
Keynote Forum: Pharmaceutical Regulatory Affairs: Open Access
Keynote Forum: Pharmaceutical Regulatory Affairs: Open Access
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