Rajak H, Parmar P, Singh A, Raghuwanshi K and Veerasamy R
Guru Ghasidas University, India
AIMST University, Malasiya
Scientific Tracks Abstracts: Pharmacoeconomics
In pursuit for better anticancer drug, and the significance of indoles and quinazolines as anticancer pharmacophore prompted us to perform the synthesis of some novel quinazolines for their anticancer activity. A series of novel Indolo[2,1-b]-quinazolinone derivatives fused with aryl sulphonamide nucleus were synthesized for their anticancer activity. The chemical structures of the compounds were elucidated by spectral (IR, 1H-NMR and MS) analyses. The anticancer activities of the compounds were investigated using MCF-7 (Breast) and A-549 (Lung) cell lines. The observed results were promising. The efforts were also made to accomplish structure-activity relationships among synthesized compounds. A novel series of indoloquinazoline possessing benzene sulphonamides were synthesized for their potential anticancer activity. These results indicate that these compounds may constitute a new class of anticancer agents.
Rajak H is a Senior Assistant Professor of Pharmaceutical Medicinal Chemistry at SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur (CG) India. In 2008, he received the Doctorate in Pharmaceutical Sciences from Dr. H S Gour University, Sagar (MP) India. His current research interest resides in synthesis and biological evaluation of small heterocyclic molecules for their anticancer activity. He has published 54 peer-reviewed articles in international scientiï¬c journals. He is dealing with several research projects funded by Government of India UGC, DST and AICTE.
Pharmacoeconomics: Open Access received 85 citations as per Google Scholar report