New Finding In Structure-Based Drug Design | Open Access Journals

Journal of Formulation Science & Bioavailability

ISSN: 2577-0543

Open Access

New Finding In Structure-Based Drug Design

The targeted delivery of potent cytotoxic molecules into cancer cells is considered a promising anticancer strategy.  There is continued interest in the field, as documented by the growing number of candidates in clinical development. This review aims to summarize the most recent innovations that have been applied to the design of ADCs undergoing early- and late-stage clinical trials.  This type of modeling is usually mentioned as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is understood as structure-based drug design. In addition to small molecules, biopharmaceuticals including peptides and particularly therapeutic antibodies are an increasingly important class of medicine and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed. It involves the study of effects of biologically active compounds on the basis of molecular interactions in terms of molecular structure or its physico-chemical properties involved.  Disposition of medicine in individual region of biosystems is one among the most factors determining the place , mode and intensity of their action .

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Citations: 23

Journal of Formulation Science & Bioavailability received 23 citations as per Google Scholar report

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