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Mast Cell | Open Access Journals
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Journal of Blood & Lymph

ISSN: 2165-7831

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Mast Cell

Mast cells are important cells of the immune system and belong to the hematopoietic line. Mast cells come from pluripotent progenitor cells in the bone marrow and mature under the influence of the c-kit ligand and stem cell factor in the presence of other distinct growth factors provided by the microenvironment of the tissue where they are intended to reside. Under normal conditions, mature mast cells do not circulate in the bloodstream. However, mast cell progenitors migrate into tissues and differentiate into mast cells under the influence of the stem cell factor and various cytokines. Mast cells are present throughout the body and play an important role in the maintenance of many physiological functions as well as in the pathophysiology of diseases. As a result, this review focuses on the role of mast cells in a wide range of physiological functions and the pathogenesis of a variety of disease states. Mast cells are found in the mucous and epithelial tissues of the whole body. In rodents, mast cells also reside in the peritoneal and thoracic cavities.

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Citations: 443

Journal of Blood & Lymph received 443 citations as per Google Scholar report

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