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Hepatotoxicity In Anti-TB Treatment | Open Access Journals

Journal of Antimicrobial Agents

ISSN: 2472-1212

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Hepatotoxicity In Anti-TB Treatment

The development of idiosyncratic hepatotoxicity is a complex process involving both simultaneous and sequential events determining the direction of the pathways, the degree of liver damage and its outcomes. Decades of clinical observation have identified a number of drug and host factors that are associated with an increased risk of anti-tuberculosis drug-induced hepatotoxicity, although the majority of studies are retrospective with case definitions and various sample sizes. Research on genetic susceptibility to hepatotoxicity has so far focused on the formation and accumulation of reactive metabolites as well as on factors that contribute to cellular antioxidant defense mechanisms and the environment that can modulate the threshold death of hepatocytes secondary to oxidative stress. Recent advances in pharmacogenetics have promised the development of refined algorithms, including drug, host and environmental risk factors, which allow better drug adaptation based on precise estimates of the benefit / risk ratio. Future investigations exploring the pathogenesis of hepatotoxicity should be carried out using human tissue and samples whenever possible, so that new findings can be easily translated into clinical applications.

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