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Biomaterials Review Articles | Open Access Journals
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Journal of Biometrics & Biostatistics

ISSN: 2155-6180

Open Access

Biomaterials Review Articles

Cell transplantation has immense potential to reverse currently incurable diseases and regenerate tissue. However, poor cell survival, cellaggregate  and lack of cell union  in the host tissue make  major challenges for the clinical translation of cell transplantation approaches. Biomaterials can influence cell behavior in vitro and in vivo. The mechanical and biochemical properties of biomaterials can be adapted to affect the survival, differentiation and migration of cells. Therefore, integrating advanced material design with stem cell biology may hold the key to improving the efficiency of cell transplantation. In this review, we discuss biomaterial design policy  for their potential to influence the fate of transplanted cells and to manipulate the host microenvironment. We are examining how the properties of biomaterials can be modulated to improve transplanted cell survival, differentiation and cell transplantation and how host tissue can be manipulated for cell transplantation by inducing plasticity and vascularization. Finally, we emphasize the importance of host immune cells for tissue repair and cell transplantation and discuss strategies to regulate the immune response by modulating the mechanical properties, architecture, chemistry and functionalization of biomaterials.

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Citations: 3496

Journal of Biometrics & Biostatistics received 3496 citations as per Google Scholar report

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