Arachidonic Acid

Various pathways using arachidonic acid (AA) as the initial substrate are composed of dioxygenases which carry out a complex reaction involving the abstraction of selected hydrogens and the insertion of molecular oxygen. Two major classes of enzymes, cyclooxygenases (COX) and lipoxygenases (LOX), are recognized for their prominent role in the generation of a number of important biological mediators. Among these, prostaglandins (PG) and leukotrienes (LT) are widely studied given their recognized role in human diseases as well as physiological and / or pathophysiological activities. Among these biological actions, one of the most important is the major role played by eicosanoids in inflammation, where they contribute to all the clinical symptoms associated with the inflammatory state, namely pain, redness and swelling . The ever-increasing number of molecules derived from AA includes other families such as lipoxins (LX), hepoxilins, hepoxides, monohydroxyeicosatretraenoic acids (HETE), dihydroxyeicosatretraenoic acids and their hydroperoxy precursors. While the synthesis of most of these mediators involves the catalytic center of non-heme iron typical of cyclo- and lipoxygenases, the hepoxilins and hepoxides come from heme proteins such as hematin and cytochrome P450.

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Biomarkers in cancer epidemiology and diagnosis: Are we ready for the prime time?
Mukesh Verma
Accepted Abstracts: Journal of Molecular Biomarkers & Diagnosis
Biomarkers in cancer epidemiology and diagnosis: Are we ready for the prime time?
Mukesh Verma
Accepted Abstracts: Molecular Biomarkers & Diagnosis
Comparison of crosslinking reagent and platelet-rich plasma therapeutic efficacies on biomechanical functions and biochemistry properties of degraded intervertebral disc? An ex vivo study using whole organ culture system
Kuo Y W, Hsu Y C, Chang Y C, Chuang I T, Lin J H, Nikkhoo M and Wang, J L
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Comparison of crosslinking reagent and platelet-rich plasma therapeutic efficacies on biomechanical functions and biochemistry properties of degraded intervertebral disc? An ex vivo study using whole organ culture system
Kuo Y W, Hsu Y C, Chang Y C, Chuang I T, Lin J H, Nikkhoo M and Wang, J L
Scientific Tracks Abstracts: Journal of Tissue Science and Engineering
Bioactive secondary metabolites from Trichoderma viride MM21
Mohamad M El-Metwally, Hamdi D Nasr, Tahia K Mohamed and Mohamed Shaaban
Posters & Accepted Abstracts: Metabolomics:Open Access
Bioactive secondary metabolites from Trichoderma viride MM21
Mohamad M El-Metwally, Hamdi D Nasr, Tahia K Mohamed and Mohamed Shaaban
Posters & Accepted Abstracts: Metabolomics:Open Access
De-differentiation: A critical malignant phenotype in glioblastoma
Narinderbir Singh, Jagat R Kanwar, Colin J Barrow and Rupinder K Kanwar
Scientific Tracks Abstracts: Metabolomics:Open Access
De-differentiation: A critical malignant phenotype in glioblastoma
Narinderbir Singh, Jagat R Kanwar, Colin J Barrow and Rupinder K Kanwar
Scientific Tracks Abstracts: Metabolomics:Open Access
Targeted metabolomics facilitates discovery of novel biomarkers of early stages of diabetes type 2 and its complications: Contributions to individualized medicine
Jerzy Adamski
Scientific Tracks Abstracts: Metabolomics:Open Access
Targeted metabolomics facilitates discovery of novel biomarkers of early stages of diabetes type 2 and its complications: Contributions to individualized medicine
Jerzy Adamski
Scientific Tracks Abstracts: Metabolomics:Open Access

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