The urgency for new and novel therapeutic agent has increased since last few decades by the serious advent of resistant pathogens and our lifestyle. The situation is becoming scary due to very less arrival of new antibiotics or other bioactive agents. Since past few years the concept of drug discovery has changed dramatically. Several modern strategies have adopted and by using different revolutionary tools and techniques and software based program it has now become easier to screen the potential strain as well as purify those highly demanding molecules. Few significant approaches that are being taken recent days to face the challenge, have discussed in this editorial.