Ricardo Gobato, Alireza Heidari
Metabolomics
Jin-Yu Che, Hong-Ying Wu, Da-Yong Lu
Obesity is a prevalence metabolic phenotype that affects social and physical nature of human beings. For obese people, life-style management plays key roles. A
small proportion of obesity persons are ineffective by lifestyle controls. Multidisciplinary medication is required.
Sandeep Kumar* and Sandeep Kumar**
Metabolomics
Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer’s, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated with any serum metabolites.
Silica nanoparticles are increasingly used in the biomedical fields due to their excellent solubility, high stability and favorable biocompatibility. However, despite being considered of low genotoxicity, their bio-related adverse effects have attracted particular concern from both the scientific field and the public. In this study, human cervical adenocarcinoma cells (HeLa line) were exposed to 0.01 or 1.0 mg/mL of hydrophilic silica nanoparticles. The 1H NMR spectroscopy coupled with multivariate statistical analysis were used to characterize the metabolic variations of intracellular metabolites and the compositional changes of the corresponding culture media. At the early stage of silica nanoparticles-exposure, no obvious dose–effect of HeLa cell metabolome was observed, which implied that cellular stress-response regulated the metabolic variations of HeLa cell.
Herein, we propose a broad updated perspective for the flux of information diagram centered in metabolomics, including the influence of other factors, such as epi genomics, diet, nutrition, and the gut- micro biome.
DOI: 10.37421/2153-0769.2021.11.294
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DOI: 10.37421/2153-0769.2021.11.293
An overview of the application of CE-MS in the field of metabolomics is provided. The study of endogenous low-molecular-weight compounds in biological samples is known as metabolomics. CE-MS has proven to be an effective technique for profiling polar metabolites in biological samples. This review discusses the application of various CE separation modes, capillary coatings, MS analyzers, sample preparation techniques, and data analysis methods . The use of CE-MS in metabolomics research is demonstrated by analysing bacterial extracts, plant extracts, urine, plasma, and cerebrospinal fluid samples. The relevant CE-MS metabolomics studies published between 2000 and 2008 are tabulated, including information on sample type and pretreatment and MS detection mode. Future developments are discussed, including the use of alternative ionization techniques, coupled separation systems, and the potential of microchip CE systems for metabolomics.
DOI: 10.37421/2153-0769.2021.11.298
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Metabolomics:Open Access received 691 citations as per Google Scholar report
