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Cardiovascular diseases remain a leading cause of mortality worldwide, urging the continual pursuit of innovative therapeutic strategies. Photodynamic Therapy (PDT) emerges as a promising technique in cardiac care, leveraging light activation of photosensitizing agents to induce localized cytotoxicity or modulate biological pathways. This abstract delves into recent advancements in PDT applications for cardiac conditions, highlighting its potential to revolutionize treatment paradigms. Firstly, we explore PDT's efficacy in treating atherosclerosis, a pivotal contributor to coronary artery disease. Preclinical studies demonstrate the capacity of PDT to selectively target atherosclerotic plaques, promoting plaque stabilization and regression while minimizing systemic side effects. Moreover, PDT's ability to modulate inflammatory responses within plaque microenvironments presents a multifaceted approach to combating atherosclerosis progression.
DOI: 10.37421/2684-4591.2024.8.225
Background: Arterial hypertension remains a significant global health burden, with a substantial proportion of patients experiencing uncontrolled blood pressure despite optimal medical therapy. Renal Denervation (RDN) has emerged as a potential therapeutic modality for such cases, offering a complementary approach to traditional pharmacotherapy.
Objective: This review aims to summarize the current evidence regarding the efficacy, safety, and potential role of renal denervation as a complementary treatment option for patients with uncontrolled arterial hypertension.
Methods: A comprehensive literature search was conducted using electronic databases including Indexed at, Embase, and Cochrane Library. Relevant studies, including randomized controlled trials, observational studies, and systematic reviews, were selected and analyzed.
Results: Several clinical trials and observational studies have demonstrated the efficacy of renal denervation in reducing blood pressure in patients with uncontrolled hypertension. Meta-analyses have shown significant reductions in both office and ambulatory blood pressure following renal denervation procedures. Additionally, RDN appears to have a favorable safety profile, with low rates of procedural complications reported in contemporary studies. However, further research is warranted to elucidate the long-term efficacy and safety of RDN, particularly in diverse patient populations and in comparison with standard medical therapy.
Conclusion: Renal denervation represents a promising complementary treatment option for patients with uncontrolled arterial hypertension despite optimal medical therapy. While current evidence suggests favourable short-term outcomes, ongoing research efforts are necessary to establish its role in routine clinical practice and to refine patient selection criteria and procedural techniques.
DOI: 10.37421/2684-4591.2024.8.226
Acute Myocardial Infarction (AMI) is a life-threatening condition characterized by the sudden interruption of blood flow to the heart muscle, leading to tissue damage and potentially fatal outcomes. Reperfusion therapy, aimed at restoring blood flow to the affected area, is the primary intervention for AMI. However, paradoxically, the process of reperfusion itself can induce additional injury, known as reperfusion injury. Understanding the underlying mechanisms of reperfusion injury is crucial for developing effective cardio protective strategies. This article explores the role of angiotensin II receptors in reperfusion injury and discusses potential therapeutic interventions targeting these receptors for cardioprotection in AMI.
DOI: 10.37421/2684-4591.2024.8.227
Medication non-adherence poses a significant challenge across various medical specialties, including rheumatology, oncology, and cardiology, compromising treatment efficacy and patient outcomes. This review synthesizes current literature to elucidate risk factors contributing to medication non-adherence in these fields and assesses interventions aimed at mitigating this issue. Common risk factors identified include complex medication regimens, financial constraints, cognitive impairment, psychological factors, and lack of social support. Interventions to improve adherence encompass multifaceted approaches, including patient education, medication simplification, technological aids (e.g., reminders, smartphone applications), behavioural interventions, and healthcare system enhancements (e.g., pharmacist-led interventions, collaborative care models). Tailored interventions, addressing specific patient needs and preferences, demonstrate promising results in enhancing medication adherence. However, the optimal strategies remain elusive, warranting further research to refine approaches tailored to the unique challenges within rheumatology, oncology, and cardiology settings. Effective adherence interventions hold the potential to optimize treatment outcomes, reduce healthcare costs, and improve patient well-being across these specialties.
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Maintaining optimal cardiac health is essential for overall well-being and longevity. With cardiovascular diseases being a leading cause of mortality worldwide, adopting effective strategies to promote heart health is crucial. In this article, we will explore some essential strategies that can help individuals safeguard their cardiac health and lead a fulfilling life.
DOI: 10.37421/2684-4591.2024.8.235
Myocardial regeneration, the process of restoring damaged heart tissue, has emerged as a promising frontier in cardiac health research. Over the
years, scientists and medical professionals have made significant strides in understanding the mechanisms behind myocardial regeneration and
developing innovative strategies to promote healing and recovery. These advancements offer new hope for patients with heart disease, paving the
way for more effective treatments and improved outcomes.
DOI: 10.37421/2684-4591.2024.8.237
Cardiac amyloidosis, once considered a rare disease, is increasingly recognized as a critical yet underdiagnosed cause of heart failure. This condition arises from the deposition of amyloid fibrils, which are misfolded protein aggregates, in the cardiac tissue. The deposits interfere with the normal function of the heart, leading to progressive heart failure and other severe cardiovascular complications.
DOI: 10.37421/2684-4591.2024.8.239
Coronary Artery Disease (CAD) remains one of the leading causes of morbidity and mortality worldwide, emphasizing the critical need for understanding its complexities, early detection and effective management. In this comprehensive guide, we delve into the intricacies of CAD, shedding light on its causes, symptoms and the array of treatment options available.
DOI: 10.37421/2684-4591.2024.8.238
Heart failure, often misunderstood as a sudden stopping of the heart, is actually a chronic condition where the heart muscle weakens and loses its ability to pump blood effectively. This critical health issue affects millions worldwide and understanding its symptoms, causes and available treatments is essential for effective management and improving quality of life.
DOI: 10.37421/2684-4591.2024.8.240
Coronary angiography is a vital diagnostic tool in cardiology, offering invaluable insights into the health of the heart's blood vessels. Understanding this procedure is essential for both patients and healthcare professionals alike. In this comprehensive guide, we delve into the intricacies of coronary angiography, shedding light on its significance in maintaining optimal heart health.
DOI: 10.37421/2684-4591.2024.8.241
In the ever-evolving field of medical technology, coronary computed tomography (CT) stands out as a revolutionary diagnostic tool that has significantly advanced our ability to detect and treat cardiovascular diseases. This sophisticated imaging technique offers a non-invasive option for assessing the health of the heart’s arteries, providing critical insights that can lead to better patient outcomes. This article explores the technological advancements, benefits and applications of coronary computed tomography in modern healthcare.
DOI: 10.37421/2684-4591.2024.8.242
Coronary microvascular dysfunction (CMD) represents a complex pathophysiological entity characterized by impaired coronary microcirculation function. While traditionally overshadowed by epicardial coronary artery disease, CMD has emerged as a significant contributor to cardiovascular morbidity and mortality. This review synthesizes the current understanding of CMD, encompassing its multifactorial etiology, including endothelial dysfunction, inflammation and metabolic derangements. Moreover, the consequences of CMD, ranging from angina pectoris to myocardial infarction and heart failure, are elucidated. Treatment strategies for CMD remain challenging due to its heterogeneous nature, but recent advancements in pharmacotherapy, lifestyle interventions and revascularization techniques offer promising avenues. This comprehensive review underscores the imperative for continued research efforts aimed at unraveling the intricate mechanisms of CMD and optimizing therapeutic approaches to mitigate its clinical impact.
DOI: 10.37421/2684-4591.2024.8.243
Echocardiography, a non-invasive imaging technique, has long been a cornerstone in the diagnosis and management of cardiovascular diseases. Over the years, significant advancements in echocardiographic technology have revolutionized the way we assess myocardial function, allowing for more accurate diagnosis and tailored treatment strategies. In particular, the evolution of myocardial imaging techniques has played a pivotal role in enhancing our understanding of various cardiac pathologies and optimizing patient care.
DOI: 10.37421/2684-4591.2024.8.234
Acute Myocardial Infarction (AMI), commonly known as a heart attack is a serious medical emergency that occurs when blood flow to a part of the heart is suddenly blocked. This blockage deprives the heart muscle of oxygen and nutrients, leading to tissue damage or cell death if not promptly treated. In this article, we will delve into the causes, symptoms, and treatment strategies for acute myocardial infarction.
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Journal of Interventional and General Cardiology received 11 citations as per Google Scholar report