Journal of Pharmacognosy & Natural Products

Department of Chemistry, Sri Sai University, Palampur, Himachal Pradesh, India

Publications

• Research Article   
  Determination of Some Sulphonyl Chlorides Using Titrimetric and Polarographic Procedures
  Author(s): Sanjay Kumar Jasrotia, Ved Parkash Patial and Shalu Shukla
  
  Reactive sulfonic acid derivatives, or sulfonyl chlorides, share characteristics and reactivity with carboxylate acid chlorides. On the other hand, the sulfonic acid group is a highly hindered molecule with substituents arranged in a tetrahedral structure. A very packed and unstable pentavalent intermediate is momentarily formed when a nucleophile attacks a sulfonyl chloride. Sulfonic acids are too hindered to allow the formation of such bulky active intermediates, in contrast to the capacity to prepare amide connections between carboxylate groups and amines using alternative condensing agents, such as carbodiimides. Sulphonyl chlorides, RSO2Cl are compounds of extensive economical, diagnostic and synthetic importance. Subsequently, their determination is of enormous opportunity and countless value. They serve as significant and inexpensive intermediates for the synthesis of economica.. Read More»
  

  Abstract PDF