Sanjay Kumar Jasrotia, Ved Parkash Patial and Shalu Shukla
Reactive sulfonic acid derivatives, or sulfonyl chlorides, share characteristics and reactivity with carboxylate acid chlorides. On the other hand, the sulfonic acid group is a highly hindered molecule with substituents arranged in a tetrahedral structure. A very packed and unstable pentavalent intermediate is momentarily formed when a nucleophile attacks a sulfonyl chloride. Sulfonic acids are too hindered to allow the formation of such bulky active intermediates, in contrast to the capacity to prepare amide connections between carboxylate groups and amines using alternative condensing agents, such as carbodiimides. Sulphonyl chlorides, RSO2Cl are compounds of extensive economical, diagnostic and synthetic importance. Subsequently, their determination is of enormous opportunity and countless value. They serve as significant and inexpensive intermediates for the synthesis of economically significant compounds such as sulphonamides, sulphonic acids, sulphonyl hydrazides, sulphones, sulphinic acids and mercaptans. Sulphonamides find wide use in chemotherapy as sulpha drugs. Utmost frequently working methods for the determination of these compounds hang on the comparatively facile splitting of their S-Cl bond in hydrolysis kind reactions with water, bases, amines and hydroxylamine, where the chloride is ejected and sulphur leftovers hexavalent in sulphonic acid or their plagiaristic formed in these reactions. Diverse approaches have been conversed and used for the determination of sulphonyl chlorides.
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