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Journal of Pharmacognosy & Natural Products

ISSN: 2472-0992

Open Access

Article in Press

Volume 7, Issue 5 (2021)

    Research Article Pages: 1 - 8

    In Vivo Effect of Medicinal Plants on Some Serum Biochemical Parameters in Laying Hens

    Muhammad Mushtaq*, Naila Chand, Sarzamin Khan, and Umer Saddique

    Effect of medicinal plants on overall performance and serological parameters were explored in the laying birds. Forty weeks old 210-egg type birds were used as tested criteria. Birds were randomly alienated to 7 experimental groups with 3 replicates, consisted of 10 birds/replicate. Data were recorded for serology and haematology of laying birds. Serum hepatic, lipids, kidney function parameters, serum antibody titre against Newcastle disease and haematological parameters were estimated at the end of trial. Significantly lower egg yolk and serum cholesterol was recorded in group Bl-1. Medicinal plants supplementation significantly lower the triglycerides level over the control group. Significantly improve/high level of high density lipoprotein was recorded in Tg-1, Bl-1 and Ta-1, while low level of low density lipoprotein was recorded in Bl-1 and Ta-1.  Haematological parameters significantly improved in medicinal plants treated groups except haemoglobin and red blood cells counts. Hepatic biomarkers ALT and AST were recorded non-significant in all treated groups, while serum ALP and total protein was significantly altered in groups Bl-1 and Ta-0.5. Non-significant observations were recorded for nephro-protective effect of medicinal plants in laying birds. It is concluded from the results that medicinal plants possess hypolipidemic, haematological and hepato-nephro protective effects.

    Volume 7, Issue 7 (2021)

      Editorial Pages: 1 - 1

      Evolution of Roman Medication through the Legendary Doctors

      Nora Davis*

      Galen, the medical man of Roman medication, created a major contribution through his teachings and writings towards moving medication forward as a profession. in contrast to those of medical man, several of Galen’s works still exist as original or ancient transcripts, some even considerably older than the Venetian printing of the Hippocratic Corpus [1]. luckily, we've got rather more autobiographic data on anatomist than medical man that enables United States to follow his career mutually of Rome’s greatest physicians and provides modern classicists like Vivian Nutton concrete proof of Galen's work and existence [2]. With twenty-one volumes still living, Galen’s individual writings square measure longer in content than the whole Hippocratic Corpus. fifty three One explicit work written by anatomist that may be explored is Delaware Optimo Medico Cognoscendo, or On Examinations by that the simplest Physicians square measure Recognized, that was written around 177CE. anatomist wrote Delaware Optimo Medico Cognoscendo to supply Romans the simplest way to research doctors, however conjointly on however a doctor will become the simplest doc.54 to grasp Galen's analysis of Roman medication, we have a tendency to 1st have to be compelled to perceive Galen's history and the way it influenced the lens from that he viewed Roman medication [3].

      Volume 7, Issue 4 (2021)

        Commentary Pages: 1 - 1

        Essential Oils of Aromatic and Medicinal Plants as Botanical Biocide for Management of Coconut Eriophyid Mite (Aceria guerreronis Keifer)

        Hadiza Fadel

        The eriophyid parasite (Aceria guerreronis Keifer) is an infinitesimal creature that stays under the perianth of the coconut and has been one of the genuine vermin of coconut throughout the previous thirty years in significant coconut developing nations. These little bugs total in states in the internal and external bracts and under the tepals and feed on the meristematic tissues on the nut surface. Because of bug assembly and taking care of the meristematic tissue underneath the perianth becomes chlorotic and afterward breaks. A. guererronis pervasion prompts surface scars, decreased organic product development, and untimely organic product fall. The announced yield misfortune brought about by A. guererronis was discovered to be 34% in India. In the previous few years, a few examinations have zeroed in on the expected utilization of fundamental oil details in natural control of different bug and illnesses. The fundamental oils which get more quickly corrupted into the climate than substance compounds have been read for their activity against different bug of put away items. Late examinations have exhibited the antilarval and antifeeding, postponed grown-up rise and egg mortality, arrestant and repellant activities of fundamental oils. The current examination has been expected to utilize these characteristic subordinates as an option ecofriendly intends to control the eriophyid bugs (A. guererronis Keifer), one of the genuine bugs of coconut.              

        Volume 7, Issue 6 (2021)

          Editorial Pages: 1 - 1

          Antidepressant like Effects of Barley (Hordeum vulgare) throughout a Mouse Model of Reserpine Induced Depression

          Thabang Lineo

          Depression may be a disorder characterized by low mood and loss of delight or interest in usual activities and sometimes leads to psychological feature disfunction like impairment of learning and memory. For most of the artificial antidepressants, severe defects like slim spectrum, adverse reactions, high drug price, and simple return exist. Barley is one among the richest sources of antioxidants; thus, we examined whether or not barley has an impact on depression, learning, and memory during a mouse model of reserpine induced depression.

          Research Article Pages: 1 - 5

          A study of the effect of an ethanolic extract of femitol on uterine fibroid in laboratory model

          Maryna Yashunina

          Uterine fibroids are becoming a common pelvic benign tumor among women of reproductive age in Ghana. This study aimed at evaluating the
          anti-fibroid property of femitol on MSG-induced uterine leiomyoma in female Sprague-Dawley rats. Total plasma cholesterol, plasma estradiol
          concentrations and uterus weight to body weight ratio were determined in normal rats, rats in which MSG (800 mg/kg) and an ethanolic extract
          of femitol (80, 160 and 400 mg/kg) had been administered concurrently for 30 days, as well as pretreatment with 800 mg kg MSG treatment for
          30 days and treated with femitol (80, 160 and 400 mg/kg) for 30 days. Acute and delayed toxicity tests were carried out to establish the safety
          for use of the extract by cage-side observation, assessing hematological, liver and kidney function. Histopathological studies on the liver and
          kidney were also performed. Total plasma cholesterol and estradiol were significant elevation (P ≤ 0.001) together with an elevation of uterus
          weight to body weight ratio by 71.55% on treating normal female rats with 800 mg kg-1 MSG. Preventive and curative treatment of MSG-treated
          animals with 80 and 160 mg/kg femitol significantly decreased (P ≤ 0.001) the elevated plasma cholesterol and estradiol with a subsequent
          lowering of uterine/body weight ratio. Pictures showed decrease uterine cell proliferation. Biochemistry results indicated no significant changes
          in liver and kidney functions. Histological studies showed no significant femitol-treatment damage in the liver and kidney. Findings suggest that
          femitol has antifibroid activity and is safe to use

          Review Article Pages: 1 - 4

          Prevalence of herbal medicine use among type II diabetic patients in Dessie Referral Hospital, Dessie, Ethiopia

          Haile Kassahun*, and Abrha Getahun

          The use of herbal medicine is prevalent among patients with chronic health problems. A research towards herbal medicine use by diabetic
          patients is limited in Ethiopia. Hence, the present study was aimed at assessing prevalence of herbal medicine use among Type II diabetic
          patients visiting diabetic clinic of Dessie referral hospital (DRH), Ethiopia. From 341 study participants, 114 (33%) of the respondents
          were used traditional herbal medicine. 41 (36%) of the participants were used herbal medicine for the treatment of DM. The most frequently
          used herbal medicines were Garlic (42%), Damakesie (18%), Aregeresa 15(13%) and Moringa 13 (11%). The use of herbal medicines
          and conventional antidiabetic medicines could cause potentially serious herb-drug interactions.

          Research Article Pages: 1 - 3

          Fruit Germination and Tissue Culture Modified MS Media Formula with Estimation of Embelin content in suspension culture by Spectrophotometric Estimation on various tabulated samples of Embelia ribes BURM.F.

          Syed Asadulla

          Germination of Fruits from Rajasthan (Ajmer) variety is Authenticated with accession Collection No. 55181e followed by Gaseous and
          surface sterilization were impinged in purified water over night and fruits mixed with concentrated Sulphuric acid for one hour and continue
          with 1% HCL moistened for one week then washed with distilled water three times and drained, and excess of acid neutralised with 10%
          calcium carbonate Washed with distilled water and confirmed that drained water is Neutral pH. Twenty fruits were transfer to a Sterilized
          petri dishes of four inch dia were opened cautiously in a laminar flow, a circular germinating paper inserted and 10 ml of Half concentration
          of MS liquid media with 1000 μ Gibbrellic acid per liter of media from (20 ml) was transferred to petri dish and 20 fruits were dispersed on
          circular special germinating filter paper and petri dish is sealed with wax elastic paper and transferred to storage racks in light and day room
          (12 hours change) at 25 degrees temperature,

          Case Report Pages: 1 - 3

          Dermatitis Skin Disorders Treated with Phyto Embryo Extracts of Cedrus Libani A. Rich: Clinical Analysis of 5 Case Reports

          Benedetto Rubetti

          The aim of present study is to evaluate the activity of Phyto embryo extracts of Cedrus libani A. Rich in integrated medicine to treat and to
          prevent some forms of dermatitis diseases. In Phytembryotherapy Cedrus libani is considered an excellent skin protector orally used in
          skin disorder's treatment. It was administrated a commercial Phyto embryo extract of Cedrus libani. Patients were monitorated for 3
          months. They were divided in two groups: 3 children (A, B, C) and 2 adults (D, E). Dosages were different in two groups: 5 drops in the morning
          for two weeks and two weeks of pause in children and 7 drops in the morning and 7 drops in the evening for 3 weeks and one week of pause in
          adults. Drops have been diluted in a small part of water. Moreover we continued the follow-up for other 12 months to verify the appareance of
          skin disorders relapses. Pruritus, dry and redness skin are disappeared in many part of the body. There are disappearance of itchy
          sensation and an improvement of symptoms of psoriatic skin. During the follow-up there are no skin disorder relapses. Before this clinical
          approach, patients did not resolve their dermatitis diseases. The combinaton with Phyto embryo extract of Cedrus libani could stimulate the
          organism about a mechanism similar to self-healing. On the basis of described studies in this article, "Cedro del Libano fee" could be
          considered an important clinical remedy to resolve forms of dermatitis

          Editorial Pages: 1 - 1

          Invariability of Some Herbal Antidiabetic Drugs in Polyherbal Formulation

          Sylbert Boakai

          In the present era, the market of all commodities has become the world. Health has been of utmost importance in past for the human race. The market of health-related merchandise has been active and these merchandise square measures factory-made in several elements of the planet and sold everywhere. Standardization is important to form positive the supply of an even product altogether elements of the planet. Standardization assures a systematically stronger product with secure constituents. flavourer formulations, in general, may be standardized schematically on formulating the medicinal drug mistreatment raw materials collected from totally different localities and a comparative chemical effectuality of various batches of the formulation is to be discovered.

          Commentary Pages: 1 - 1

          Protective Effects of Picrorhiza Kurroa on Cyclophosphamide-Induced Immunological Disorder in Mice

          Komlan Paul

          On stepping into the twenty first century, we've got subjected ourselves to such an inclined surroundings that it's virtually become not possible for our natural system to convey America the fair proportion of protection from the antigens. Natural product resources offer the wonderful raw materials for the invention and development of novel immunomodulatory compounds. Immunomodulatory medicative plants are relatively a recent idea in pharmacognosy.

          Commentry Pages: 1 - 2

          Antimicrobial activity and chemical composition of oils of Juniperus excelsa Bieb (Cupressaceae) grown in R Macedonia

          Berenike Axios

          Juniperus is one among the main genera of family Cupressaceae family consisting of roughly seventy species. Juniperus excelsa Bieb. is massive ligneous plant or tree, unfold chiefly throughout the japanese Mediterranean ranging from north-eastern Ellas and southern Balkan nation across Turkey to the Middle-East countries (Syria and Lebanon) and also the mountain range.

          Editorial Pages: 1 - 1

          Applications of Marine Microbial Pharmacognosy

          Flemming Morsch

          The success of modern pharmaceuticals is one of the main achievements of the 20th century. Drugs such as penicillin, streptomycin, and vincristine, among others, have contributed greatly to human disease control since their emergence early in the 20th century. New drug treatments have increased the length of human life and enhanced the quality of life. Society has become increasingly dependent on the availability of safe and effective pharmaceutical products in this respect.

          Full Length Research Paper Pages: 1 - 2

          Antihyperlipidemic Activity of Ginger and Green Tea and Honey

          Megha Salve

          The hyperlipidaemia is the condition in which extra fats are deposited on tissue of organs of body. The high lipid level in body shows the coronary artery disease and heart diseases. It also cause the hypertension and also affect on kidney. These conditions also treat by allopathic drug like statin and vitamin B3. The high level of lipid or fat are harmful to health is also cause death. The hyperlipidemia are cause due to improper diet, consumption of alcohol, icecream and oily foods, etc. The green tea is antioxidant, anticancer, antibacterial, antimicrobial properties and also control the level of cholesterol. Green tea helps to treat the hyperlipidaemia. The various active components of green tea are theophylline, theobromine, caffeine, catechine and epigalepigallocatechine. The most active componet i.e epigallocatechine are responsible to treat the hyperlipidemia. The ginger is antioxidant, antiinflammatory, antifungal, antimicrobial and Antihyperlipidemic properties. The active component of gineger is gingerol help to treat the hyperlipidemia. The honey is the source of sugar. It act as antioxidant and also show Antihyperlipidemic property. It also helpful to increase the digestion.This research study shows the Antihyperlipidemic activity of green tea, ginger and honey. Both are helpful to reduce the lipid level of body and maintain the health of heart, and other body organs also

          Editorial Pages: 1 - 1

          The Anticancer Drug Discovery from Marine Invertebrates

          Chin Yung Han

          Medicines are medically prescribed treatments for the improvement of disease conditions, the restoration of good health and human vitality. Marine medicine, in relation to ocean derivatives, is the restoration of fitness. Via prevention and care as medicine, it includes a number of procedures using marine species to preserve health. Marine medicine is a science of prevention and recovery in relation to ocean derivatives to cure, preserve and restore health. It has a corollary area called Dive Medicine that is related. The marine ecosystem is a source of specific natural products that accumulate primarily in living organisms and function as pharmacologically active substances that are useful. Significant sources of biomedical compounds include marine sponges, molluscans, bacteria, corals, ascidians, bryozoans and vertebrates

          Editorials Pages: 1 - 2

          Formulation and Evaluation of Herbal Facewash for Antimicrobial Activity

          Santhosh Kumar Banotha

          Herbal medicines, sometimes referred to as Herbalism or Botanical medicine.is the use of herbs for their therapeutic or medicinal value. An herb is a plant or plant part valued for its medicinal, aromatic qualities. Herb plants produce and contain a variety of chemical substances that act upon the body. Herbal medicines the oldest form of health care known to mankind. Herbs had been used by all cultures throughout history.

          Research Article Pages: 1 - 6

          Analgesic Effect of Citrullus Colocynthis (L.) Schrad. On Chronic Constriction Injury and Spared Nerve Injury Models of Neuropathic Pain, an In Vivo Study

          Mohammad H Karimipour Baseri*

          Objective: Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) has many therapeutic effects such as anti-diabetic, antiinflammatory, and analgesic effects. In this study, the effectiveness of fruit pulp of this plant on peripheral neuropathy in two models of sciatic nerve pain. Materials and Methods: The fruit of plant, once collected, dried, then powdered and extracted by ultrasonic using ethanol solvent and condensed and dried for further steps. Pharmacologically, the analgesic effect of mentioned extract was evaluated. The chronic constriction injury (CCI) was inducing by placing four loose ligatures around the sciatic nerve, proximal to its trifurcation and spared nerve injury (SNI), Cut off one branches of the three root of the sciatic nerve output and pull it forward. Then, in both cases CCI and SNI muscle and skin suture separately. Locomotors activity, paw withdrawal cold allodynia and paw withdrawal thermal latency (thermal hyperalgesia) of rats were measured on 3, 7,10 and 14 post operated day and calcium content and pathologic were measure in nerve tissue. Results: A 14-day treatment with extract (1, 2, and 3mg/kg, i.p.) for different days starting from the 1st day after CCI operation significantly attenuated locomotors activity and paw withdrawal thermal latency. Ethanol extract also decreased lipid peroxidase and myeloperoxidase activity. However, administration of the extract for 14 day significantly attenuated chronic constriction injury-induced neuropathic pain and also decreased the oxidative stress and calcium level. Conclusion: The results of this study suggest that Citrullus colocynthis extract could be useful in the treatment of different kinds of neuropathic pains and as an adjuvant to conventional medicines.

          Research Article Pages: 1 - 6

          Ethanol Leaf Extract of Moringa Oleifera Mitigates Glycerol- Induced Acute Kidney Damage in Rats Through Down Regulation of Kim-1 and Nf-╬?b Signaling Pathways

          Adeolu Adedapo, Ademola Oyagbemi, Temidayo Omobowale

          Background: Acute kidney injury is a serious medical condition that usually results in sudden loss of renal function and high mortality
          rate in the world. The efficacy and the mechanisms of ethanol leaf extract of Moringa oleifera in promoting recovery from glycerol induced
          Acute Kidney Injury (AKI) in rats was investigated in this study.
          Methods: Thirty-five adult male Wistar rats were randomly sorted into five groups of seven animals each. Control received distilled
          water alone, Untreated group received single glycerol (4 ml/kg) intramuscularly, two groups were pretreated orally with 50 and 100 mg/kg of
          Moringa oleifera respectively for seven days and then injected with a single glycerol (4ml/kg) subcutaneously on day eight. Another
          group received oral administration of Moringa oleifera alone at 100 mg/kg for seven days. The animals were later sacrificed through cervical
          dislocation twenty-four hours after glycerol was administered.
          Results: Serum and renal homogenate analysis revealed that glycerol induced significant increases in creatinine kinase renal band, nitric
          oxide, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products alongside a decrease in superoxide
          dismutase, reduced glutathione, glutathione peroxidase and an increase in the expression of Kidney Injury Molecule-1 (KIM-1) and Nuclear
          Factor Kappa Beta (NF-kB) using immunohistochemistry. Treatment with Moringa oleifera at both doses used brought on a reversal of these.
          Conclusion: These results support the hypothesis that oral administration of methanol stem extract of Moringa oleifera is effective in abrogating
          oxidative stress, attenuating inflammation, and enhancing nephrogenic repair after glycerol-induced AKI.

          Research Article Pages: 1 - 8

          In Vivo Effect of Medicinal Plants on Some Serum Biochemical Parameters in Laying Hens

          Muhammad Mushtaq, Naila Chand, Sarzamin Khan, and Umer Saddique

          Effect of medicinal plants on overall performance and serological parameters were explored in the laying birds. Forty weeks old 210-egg type birds were used as tested criteria. Birds were randomly alienated to 7 experimental groups with 3 replicates, consisted of 10 birds/ replicate. Data were recorded for serology and haematology of laying birds. Serum hepatic, lipids, kidney function parameters, serum antibody titre against Newcastle disease and haematological parameters were estimated at the end of trial. Significantly lower egg yolk and serum cholesterol was recorded in group Bl-1. Medicinal plants supplementation significantly lower the triglycerides level over the control group. Significantly improve/high level of high density lipoprotein was recorded in Tg-1, Bl-1 and Ta-1, while low level of low density lipoprotein was recorded in Bl-1 and Ta-1. Haematological parameters significantly improved in medicinal plants treated groups except haemoglobin and red blood cells counts. Hepatic biomarkers ALT and AST were recorded non-significant in all treated groups, while serum ALP and total protein was significantly altered in groups Bl-1 and Ta-0.5. Non-significant observations were recorded for nephro-protective effect of medicinal plants in laying birds. It is concluded from the results that medicinal plants possess hypolipidemic, haematological and hepato-nephro protective effects.

          Editorial Pages: 1 - 1

          Abiotic Therapeutic Effect on Artificial Environmental Condition

          Thomas Lebron*

          High soil salinity is taken into account a serious threat for agricultural productivity in dry or coastal areas because of its enlarged incidence in irrigated lands that account for a serious a part of world food production (Flowers 2004). Thus, salinity is additionally a vital abiotic stress limiting (tomato) crop cultivation. Salt stress persistence twelve throughout the plants’ lifespan doubtless ends up in co-occurrence with further stress factors, either abiotic (e.g. heat, drought) or organic phenomenon (fungi, insects etc.) justifying any analysis on the impact of stress combos that embrace salinity.

          Commentary Pages: 1 - 1

          Bio-assay uses and pharmacological Activity in Aden asp

          Trevor Andres*

          Livestock production systems are key components of worldwiseacre culture; it has been calculable that half-hour of the world’s economic output comes from this sector This sector is more and more organized in long market chains using roughly one.3 billion folks globally and directly supporting the livelihoods of 600 million demesne farmers in developing countries In each developed and developing countries, placental square measure used as sources raw materials for leather industry, human food and fiberboard covering. Placental species conjointly play important further economic and socio-cultural roles for the upbeat of rural households in developing countries. Thus, they square measure used not solely as food supply and source of financial gain, however conjointly plus saving, supply of employment, soil fertility building, transport, agricultural traction, agricultural diversification and its property production In Africa, the range of oxen associated/or small ruminants in hand is symbolic of an individual’s wealth and standing within the society. Placental parasitic infections square measure one of the main constraints for each small-and largescale farmer. In explicit, helminthosis is a serious drawback inflicting important economic losses and threatening food security in numerous ways that These losses will be manifested by lowered fertility, reduced work capacity and breeding potency, involuntary culling, a discount in food intake and weight gain, reduced immunity to alternative pathogens, lower milk production, treatment prices, and mortality in heavily parasitized animals. The bioassay-guided fractionations of Aden asp. Water crude extract and tending characterization of Bio-Gel P-2 fractions discovered that active constituents were partitioned into a tiny low variety of fractions supported their molecular sizes. As such, outcomes on Addenda sp. obtained here are in agreement with several reports on compounds isolated and sublimate by bioassay-guided isolation and purifications mentioned. Chromatograms examined beneath UV-light shown that Aden asp. Water extract didn't contain any fluorescent spot. Such a result may indicate the absence of metabolites with UV-active chemical group useful group sin the extract. From Bio-Gel P-2 fractionations of Aden asp, it was noted

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