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Nuclear Medicine & Radiation Therapy

ISSN: 2155-9619

Open Access

J.N. Sarkaria

Department of Radiation Oncology, Mayo Clinic; Rochester, MN, USA

Publications
  • Short Communication   
    Ascorbate Preferentially Stimulates Gallium-67 Uptake in Glioblastoma Cells
    Author(s): Michael S. Petronek*, M. Li, J.N. Sarkaria, M.K. Schultz and B.G. Allen

    Gallium is a tri-valent p-block metal that closely mimics tri-valent iron. Gallium is internalized into cells via transferrin receptor-mediated endocytosis. Both Ga-67 and Ga-68 are radionuclides that can be radiolabeled to various bioactive compounds for clinical imaging procedures to visualize tumors and sites of inflammation. High-dose ascorbate (pharmacological ascorbate) is an emergent glioblastoma therapy that enhances cancer cell-killing through iron-metabolic perturbations. We hypothesized that pharmacological ascorbate treatments might alter Ga-67 uptake in glioblastoma cells. We evaluated the in vitro ability of pharmacological ascorbate to alter gallium uptake in patient-derived glioblastoma cells with variable genetic backgrounds by co-incubating cells with Ga-67 ± pharmacological ascorbate. Surprisingly, we observed increased basal gall.. Read More»
    DOI: 10.37421/2155-9619.2022.13.491

    Abstract HTML PDF

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Citations: 706

Nuclear Medicine & Radiation Therapy received 706 citations as per Google Scholar report

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