Nuclear Medicine & Radiation Therapy

ISSN: 2155-9619

Open Access

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    Full Length Research Paper Pages: 1 - 3

    Evaluating the Radiation Dose Hazardous Indexes Using Hpge Detector in Sekota, Ethiopia

    Baye Zinabe Kebede*

    This research paper desired to illustrate the presence of naturally occurring radioactive minerals concentration and the way how naturally occurring radioactive minerals were identified in Wag-himra iron ore deposit soil site. The deposit area covers five Kebelles of the border of Sekota wereda, Ziquale and Abergelle wereda. We were used HPGe detector to identify the presence of natural occurring radioactivity concentration in iron ore/alloy deposit soil, and applied appropriate research methodology particularly experimental design were more preferable. The researcher was collected samples from ten places across iron ore deposit area by using critical sampling techniques and prepared as a desirable manner. The chosen sample was sealed for four weeks in order to obtain secular equilibrium, wherein the rate of decay of the daughters’ equivalent that of the parent. Radium equivalent activity, external hazard index and representative gamma index of the sample were 56.19 Bq/kg,0.1515 Bq/kg,0.804 Bq/kg,0.408Bq/kg,0.00011 Bq/kg respectively. However, internal hazard index was slightly approaching to recommended value and it may cause the significant radiation hazard through long dwelling to the area.

      Research Article Pages: 1 - 4

      Radiation Dose to Nuclear Medicine Technologist During Manual Synthesis of High Specific Activity Non-Carrier Added Lu177 Labelled Radio pharmaceuticals

      Sarepaka V Ramana Murthy

      Introduction: Technologists working in Nuclear Medicine are exposed to radiation when doing tasks such as labeling/synthesis of radiopharmaceuticals, radiopharmaceutical administration, scan acquisition, and radiation survey. When working with therapeutic radiopharmaceuticals, the radiation dose could be significantly higher. The radiation dosage to the technologist in this study involved synthesis of Lu-177-DOTATATE (DOTA-Tyr3-octreotate) and PSMA-617(Prostate specific membrane Antigen) was estimated. Aim: The purpose of this study is to calculate the whole-body radiation dose to a technologist who is involved in the labelling of two different Lu-177 labelled compounds, namely Lu-177 DOTATATE and Lu-177- PSMA, and to compare the occupational burden to the dose limits recommended by India's Atomic Energy Regulatory Board. Materials and methods: A survey meter cum contamination monitor was used to detect radiation levels before the start of the labelling in the Hot lab by maintaining it at the area where the technologist generally stands during synthesis. An instant personal monitoring device like electronic pocket dosimeter was used by the technologist at chest level, performing the labelling of Lu177 (135mci to 520mci) received fortnightly by our department. Data were collected for 16 syntheses of Lu-177 DOTATATE and13 syntheses of Lu-177 PSMA-617 followed by the quality control. Mean time required to complete synthesis of Lu-177 DOTATATE and Lu-177 PSMA-617 was 52.68min and 52.39min respectively. Mean whole body radiation dose was 0.041 ± 0.004 mSv and 0.037±0.002mSv. Higher dose was obtained during the synthesis of Lu-177 DOTATATE. Conclusion: Data suggest that during the manual radio labelling of Lu -177 compounds, the whole-body radiation exposure to technologist is within the limits prescribed by AERB.

        Research Article Pages: 1 - 4

        The Value of 18F-FDG PET/CT in Detecting Local Recurrence or Distant Metastases in Patients with Renal Cell Carcinoma Who Underwent Radical Nephrectomy

        Ai-ka Abneh Awad* and Attieh Ola

        Aim: The aim of this study is to detect the value of 18F-FDG PET/CT in detecting local recurrence or distant metastases in patient who underwent radical nephrectomy for renal cell carcinoma.

        Materials and Methods: This retrospective study includes 88 patients diagnosed to have renal cell carcinoma underwent radical nephrectomy. Both 18F-FDG PET/CT and CT scan were done in the post-operative period for follow up. Sites of the relapse were categorized into local recurrence and distant metastasis. The final diagnosis of disease status was made on subsequent follow up by conventional imaging CT and 18F-FDG PET/CT with histopathology confirmation for all of the cases.

        Results: PET/CT was positive and detected recurrence in 48/88 patients, of which confirmed to be recurrence via biopsy 46/48 and was negative in 40/88 patients, 3 of them were falsely negative. 11/48 had local renal bed recurrence and 35/48 patients had distant metastases. PET/CT classified: 46/48 of cases to be true-positive, 2/48 false-positive and 3/40 false-negatives. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 93.9%, 94.9%, 94.3%, 95.8%, and 92.5%, respectively.

        Conclusion: 18F-FDG PET/CT scan proved its efficiency in post-surgical renal cell carcinoma patients as a follow up tool in local recurrence and distant metastasis. In particular detection of renal bed recurrence and bone metastasis. This can be considered as a base for future studies with larger population number.

          Research Article Pages: 1 - 9

          Radioprotective Efficacy of Marine Algae

          Subhashini Swaminathan* and Shweta Kailash Pal

          Radiation and radiation technology has risen too much from the last few years, hence the chances of radiation contamination increased over the past few years. The need to study radiation protection has become necessary. Commercially available chemical radioprotectors having too many side effects and hence limiting the use. Since the last decade, the study on marine algae has gained impact through the experimental studies marine algae is considered to have many Radioprotective phytochemicals, such as phlorotannins, polysaccharides, carotenoids and other compounds. Chemical radioprotectors having many side effects of the human hence limiting the use. Natural radioprotectors can be used in place of artificial to reduce the side effect and can be used in the long run. Marine algae exhibiting a broad spectrum of antioxidant properties can be used widely as radioprotectors.

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