Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Gaetano Lucania

Dr, Department of Hematology, Troyes General Hospital, Troyes, France

  • Review Article   
    The New Era for Advancements in Peripheral T-Cell Lymphoma: A Review
    Author(s): Srimanta Chandra Misra*, Gaetano Lucania, Valentina Guarino and Alberto Santagostino

    Peripheral T-Cell Lymphomas (PTCL) are an uncommon and heterogeneous group of disorders arising from the innate and adaptive immune system. This review deals with the basis and major revisions to the current PTCL classification. Each entity in the 2016 classification has been reviewed on the basis of cell origin, genetic landscape and recent therapeutic options. The objective of this study was to conduct a review of the normal immune system, signalling pathways and tumor microenvironment in order to understand the heterogeneity of certain entities as well as to uncover the potential therapeutics. A brief evaluation of a normal immune system, implication of the JAK-STAT pathway and tumor microenvironment was performed to explain the heterogeneity of PTCL. Attempts were also made to optimize current standard and personalized management approaches. Fulfilling the curren.. Read More»
    DOI: 10.37421/ 2165-7831.2023.13.303

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Citations: 443

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