Nuclear Medicine & Radiation Therapy

Yoshiaki Yura

Publications

• Research Article
  Boron Carbide Particle as a Boron Compound for Boron Neutron Capture Therapy
  Author(s): Takaki Iwagami, Yoshie Ishikawa, Naoto Koshizaki, Naofumi Yamamoto, Hiroki Tanaka, Shin-ichiro Masunaga, Yoshinori Sakurai, Itsuro Kato, Soichi Iwai, Minoru Suzuki and Yoshiaki YuraTakaki Iwagami, Yoshie Ishikawa, Naoto Koshizaki, Naofumi Yamamoto, Hiroki Tanaka, Shin-ichiro Masunaga, Yoshinori Sakurai, Itsuro Kato, Soichi Iwai, Minoru Suzuki and Yoshiaki Yura
  
  Background: In boron neutron capture therapy (BNCT), the intravenous administration of boron-containing compounds such as boronophenylalanine (BPA) and borocaptate sodium (BSH) is followed by irradiation with thermal neutrons. In the present study, we determined whether a boron-rich boron carbide (B4C) nanoparticle could be used for BNCT. Methods: B4C nanoparticles were obtained by the laser fragmentation of boron particles in ethyl acetate. Neutron irradiation was delivered via a neutron beam at the Kyoto University Research Reactor (KUR). Results: Cell viability was lower in oral squamous cell carcinoma (SCC) cells exposed to neutrons in the presence of B4C particles than in those exposed to neutrons only. The combination of B4C particles and neutron irradiation also decreased the formation of colonies.Injecting B4C particles into the .. Read More»
  DOI: 10.4172/2155-9619.1000177

  Abstract PDF