Journal of Blood & Lymph

Koji Ishii

Publications

• Research Article
  Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load
  Author(s): Kaori Kanayama, Koji Ishii, Mie Shinohara, Michio Kogame and Yasukiyo SuminoKaori Kanayama, Koji Ishii, Mie Shinohara, Michio Kogame and Yasukiyo Sumino
  
   Background: We have been investigating serial changes in Type I Interferon (IFN) receptor alpha-2 (IFNAR-2) expression in peripheral blood leukocyte subsets in Chronic Hepatitis C (CHC) patients during IFN-based therapy. The aim of this study was to clarify whether changes in IFNAR-2 expression by peripheral blood leukocyte subsets are predictive factors for Sustained Virological Response (SVR). Methods: One hundred and thirty-six patients with CHC and receiving Pegylated (PEG)-IFN alpha-2a or -2b in combination with ribavirin (RBV) for a median 48 (16-96) weeks were studied. A negative result for serum HCV-RNA on RT-PCR at week 24 after the End Of Therapy (EOT) was defined as SVR. IFNAR-2 expression by peripheral blood leukocyte subsets was quantified using flow cytometry by measuring the mean fluorescence intensity before and up to 2.. Read More»
  DOI: 10.4172/2165-7831.1000109

  Abstract PDF