Transplantation Technologies & Research

ISSN: 2161-0991

Open Access

Ajay Sharma

United Kingdom

  • Review Article
    Basiliximab in High-risk Group: An African View
    Author(s): Jacob Olugbenga Awobusuyi, Julie M Bridson, Ajay Sharma and Ahmed HalawaJacob Olugbenga Awobusuyi, Julie M Bridson, Ajay Sharma and Ahmed Halawa

    In organ transplantation, a wide variety of injurious events such as ischaemia-reperfusion injury, endothelial damage and the traumatic exposure of tissues during surgery occur intra-operatively. The barrage of multiple antigens presented to the recipient cause very intense immunological reaction to occur at the time of transplantation. Thus, an induction immunosuppressive protocol aimed at maximal immunosuppression in the peri-operative period when immunological stimulation is maximal is justified. Organ transplant recipients of African descent are generally considered as high immunological-risk patients in view of the intense immunological response to transplanted organs seen in these patients compared with their Caucasian counterparts. However, due to the huge additional cost of induction antibody medications, most centers in resource-poor economies in Africa base their ind.. Read More»

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