Hirokazu Miki*
Multiple Myeloma (MM) remains incurable and thus, innovative therapeutic options are needed. MM cells not only reside in the bone marrow, but also expand outside bone. The extramedullary expansion of plasmacytoma is generally accepted to represent a high-risk condition with more aggressive features and a poorer prognosis. Therefore, novel therapeutic options with different modes of action against MM and extramedullary plasmacytoma need to be developed. Hyperthermia is an ancient and unique treatment option for cancers. We previously reported the anti-MM effects of hyperthermia combined with proteasome inhibitors. To apply the cytotoxic effect of hyperthermia, we developed novel superparamagnetic nanoparticles, which accumulate in extramedullary tumors in mouse plasmacytoma models and generate heat locally with alternative magnetic currency. This commentary provides detailed insights into the mechanisms of action and therapeutic potential of hyperthermia for plasma cell dyscrasias.
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Journal of Blood & Lymph received 443 citations as per Google Scholar report
