The tail-cuff method was used to assess systolic blood pressure, as previously described. At 48 weeks of age, the rats were assessed, with 2 days of tail-cuff blood pressure training followed by 3 days of measurements. On each measurement day, two sets of measurements were taken, each with up to five independent measurements. Animals were tested on a daily basis at roughly the same time.
Stroke is the leading cause of motor impairments and a leading cause of death around the world. Adult stem cells have been found to protect neurons from degeneration through mechanisms that include neurotransmitter activity recovery as well as a reduction in apoptosis and oxidative stress. As a model for stem cells, we used the lineage stroke-prone spontaneously hypertensive rat (SHRSP).Recent research suggests that to restore the loss of cells in the nervous system, particular combinations of therapies are required, based on the already existing neural network as well as the blood supply and intrinsic mechanisms of healing. MSCs have been shown to give birth to neural cells in vitro and in vivo in numerous investigations. Bone marrow stem cells may become involved after an ischemic eventHTML PDF
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