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Journal of Vasculitis

ISSN: 2471-9544

Open Access

Articles in press and Articles in process

    Commentary Pages: 1 - 1

    Lymphocytic Vasculitis Differential Diagnosis

    Sergey David

    Lymphocytic vasculitis is one in all many skin conditions that square measure conjointly noted as body covering vasculitis. In white corpuscle vasculitis, white blood cells (lymphocytes) cause harm to blood vessels within the skin. This condition is assumed to be caused by a variety of things; however, the precise explanation for most cases isn't celebrated. This sickness will gift with a range of symptoms, reckoning on the scale, location, and severity of the affected space. In a very minority of patients, the body covering vasculitis may be a part of a lot of severe vasculitides poignant different organs within the body this can be called general vasculitis. Lymphocytic inflammation is assumed to be caused by variety of various factors, like infection, trauma, drug reaction, or AN underlying condition like inflammatory disease. As a result of this condition is rare and not nevertheless well understood, it's believed that a full list of doable causes has nevertheless to be assembled. Lymphocytic inflammation will cause variety of various symptoms. Hives, red or chromatic discoloured patches, a bump (nodule), or AN open sore (ulcer) have all been delineate as symptoms of this condition. The size, location, and severity of symptoms vary wide among affected people.

    Short Communication Pages: 1 - 2

    How does Corticosteroid Reduce Inflammation?

    Ahmed Sharifa

    Corticosteroids area unit a category of drugs that lowers inflammation within the body. They additionally cut back system activity. As a result of corticosteroids ease swelling, itching, redness, and allergies, doctors usually impose them to assist treat diseases like respiratory disease, arthritis, lupus, and allergies. Corticosteroids fit corticosteroids, a secretion naturally made by the body’s adrenal glands. The body wants corticosteroids to remain healthy. Corticosteroids could be a major player in a very big selection of processes within the body, together with metabolism, immune reaction, and stress.

    Short Communication Pages: 1 - 2

    How Does Corticosteroid Medication Effect Immune System

    Yelena Shannan*

    Corticosteroids square measure secretion mediators created by the cortex of adrenal glands that additionally categorize into glucocorticoids, mineralocorticoids, and steroid sex hormones. They're employed in an excessiveness of conditions, ordinarily known as steroid-responsive disorders and dermatoses. Corticosteroids represent an ambiguous weapon system - vital profit with a coffee incidence of adverse effects may be expected if employed incorrect dose and for a restricted duration; but, wrong dose and/or length and unmindful withdrawal when prolonged administration will have harmful effects.

    Short Communication Pages: 1 - 2

    Cryoglobulinemic Vasculitis Treatments

    Gary S Hoffman

    Cryoglobulins area unit proteins found within the blood that precipitate (clump together) within the cold and will cause inflammation and organ injury. However, these proteins also can be a gift in low levels within the blood while not inflicting any symptoms. once there are unit symptoms thanks to the cryoglobulins, the unwellness (usually a special rash) is named "cryoglobulinemia." Cryoglobulinemia may be present alone ("idiopathic") or may be related to different diseases such as Infection, significant hepatitis C infection, Blood cell abnormalities like malignant neoplastic disease and myeloma, Connective tissue malady like lupus.

      Editorial Pages: 1 - 1

      An Editorial on Hypersensitivity Vasculitis

      Yelena Shannan*

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      Perspective Article Pages: 1 - 2

      Cutaneous Small Vessel Vasculitis Due to Dolutegravir: A Rare Side Effect of Dolutegravir Based HAART Regimen in PLHIV

      Suvesh Singh, Bhavya Swarnkar*, Neetu Bhari and Akash Deep Chandra

      DOI: DOI: 10.37421/2471-9544.2022.8.154

      According to World Health Organization (WHO), Dolutegravir-based regimen is considered as first-line therapy for PLHIV and strongly recommended for all adults and children at the 10th International AIDS Society Conference on HIV Science (IAS 2019) held in Mexico City. Dolutegravir (integrase inhibitor) is pharmacokinetically favorable with a single daily dose, fewer drug interactions, superior potency against HIV-1, and potency against efavirenz-resistant virus. In 2020, NACO announced the phase-wise replacement of TLE regimen to TLD regimen.

        Editorial Pages: 1 - 1

        Editorial on Inflammatory Bowel Disease

        Yelena Shannan

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        Perspective Pages: 1 - 1

        Perspective on Golfer's Vasculitis

        Yelena Shannan*

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        Commentary Pages: 1 - 1

        An Overview on Rheumatoid Vasculitis

        Yelena Shannan*

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        Commentary Pages: 0 - 1

        Is Lupus Constant as Rheumatoid Arthritis?

        Stefania Cunningham*

        The system of the body attacks its own tissue, as well as joints, in rheumatism. It attacks internal organs in severe cases. Arthritis affects the linings of the joints, inflicting painful swelling. The inflammation related to autoimmune disease will cause bone erosion and joint deformity over time. Whereas there's no cure for autoimmune disease, physiatrists and drugs will facilitate slow the progression of the sickness. The bulk of cases are often managed with a category of medicines called anti-rheumatic medicine. Autoimmune disease, or RA, is associate degree response and disease within which your system erroneously attacks healthy cells in your body, leading to inflammation. RA primarily affects the joints, and it always affects many joints at constant time.

          Review Article Pages: 1 - 9

          Glucocorticoids Induced Adverse Events in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Are Frequent and Often Severe, but Under-Reported: A Systematic Review

          Tejas Thomas*, Dieter Götte, Bernhard Hellmich, Duvuru Geetha, Peter Antony Rutherford, Kumari Priyanka

          Background: Glucocorticoids are cornerstone for treatment of anti-neutrophil cytoplasmic Antibody-Associated Vasculitis (AAV) but
          their significant dose-dependent toxicity is a major concern in clinical practice. This systematic review aims to determine the frequency
          and proportion of glucocorticoid-related adverse events in patients with AAV.
          Method: A systematic literature search was performed in the Embase, Medline and PubMed databases with limitation on years of publication
          between January 2000 and December 2020. Full text articles from randomized controlled trials, other interventional and observational
          studies including data on the study design, population size, drugs administered and adverse events reported were considered for the
          analyses. Studies focused exclusively on eosinophilic granulomatosis with polyangiitis were excluded. A regression model was run to
          explore the relationship between mean doses of glucocorticoids, duration and reported adverse events. Furthermore, a correlation matrix
          was generated to analyse the rate of incidence of adverse events.
          Results: A total of 91 articles were reviewed. Most frequently reported serious adverse events included death (12%) and severe infections
          (9%) while non-serious adverse events included infections (not specified) and leukocytopenia (approximately 14%each). Diabetes was
          frequently reported according to the Vasculitis Damage Index components. Regression analysis revealed a significant association between
          duration of glucocorticoid treatment and occurrence of infections and eye disorders (not specified, p<0.05). There was no significant
          association between the mean glucocorticoid dose and occurrence of reported adverse events.
          Conclusion: The increasing clinical burden of glucocorticoid-related adverse events in patients with AAV could be reduced by considering
          advanced therapeutic strategies.

            Case Report Pages: 1 - 4

            Unusual Form of Kidney Injury without Glomerulonephritis in Microscopic Polyangiitis

            Cihan Uysal*, Tugba Yilmaz, Hafsa Kocyigit, Hulya Akgun and Murat Hayri Sipahioglu

            ANCA test has diagnostic significance on AAV. The Immunofluorescence Assay (IFA) usually has a perinuclear staining pattern (PANCA), and Enzyme-Linked Immuno Sorbent Assays (ELISA) detect antibodies to Myeloperoxidase (MPO-ANCA) in MPA. Kidney involvement is noted in approximately 80-100 percent of patients with MPA cases, and the clinic spectrum range from microscopic hematuria to severe kidney injury with dialysis requirement. Pulmonary involvement is noted in approximately 25-55 percent of patients with MPA. Several observations and presumptions have been noted about TIN accompanying crescentic glomerulonephritis. This diversity may be considered as only a simple histological elaboration. However, it is a significant clinical entity for guiding the treatment.

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