Tejas Thomas*, Dieter Götte, Bernhard Hellmich, Duvuru Geetha, Peter Antony Rutherford, Kumari Priyanka
Background: Glucocorticoids are cornerstone for treatment of anti-neutrophil cytoplasmic Antibody-Associated Vasculitis (AAV) but
their significant dose-dependent toxicity is a major concern in clinical practice. This systematic review aims to determine the frequency
and proportion of glucocorticoid-related adverse events in patients with AAV.
Method: A systematic literature search was performed in the Embase, Medline and PubMed databases with limitation on years of publication
between January 2000 and December 2020. Full text articles from randomized controlled trials, other interventional and observational
studies including data on the study design, population size, drugs administered and adverse events reported were considered for the
analyses. Studies focused exclusively on eosinophilic granulomatosis with polyangiitis were excluded. A regression model was run to
explore the relationship between mean doses of glucocorticoids, duration and reported adverse events. Furthermore, a correlation matrix
was generated to analyse the rate of incidence of adverse events.
Results: A total of 91 articles were reviewed. Most frequently reported serious adverse events included death (12%) and severe infections
(9%) while non-serious adverse events included infections (not specified) and leukocytopenia (approximately 14%each). Diabetes was
frequently reported according to the Vasculitis Damage Index components. Regression analysis revealed a significant association between
duration of glucocorticoid treatment and occurrence of infections and eye disorders (not specified, p<0.05). There was no significant
association between the mean glucocorticoid dose and occurrence of reported adverse events.
Conclusion: The increasing clinical burden of glucocorticoid-related adverse events in patients with AAV could be reduced by considering
advanced therapeutic strategies.
Cihan Uysal*, Tugba Yilmaz, Hafsa Kocyigit, Hulya Akgun and Murat Hayri Sipahioglu
DOI: DOI: 10.37421/2471-9544.2022.8.159
ANCA test has diagnostic significance on AAV. The Immunofluorescence Assay (IFA) usually has a perinuclear staining pattern (PANCA), and Enzyme-Linked Immuno Sorbent Assays (ELISA) detect antibodies to Myeloperoxidase (MPO-ANCA) in MPA. Kidney involvement is noted in approximately 80-100 percent of patients with MPA cases, and the clinic spectrum range from microscopic hematuria to severe kidney injury with dialysis requirement. Pulmonary involvement is noted in approximately 25-55 percent of patients with MPA. Several observations and presumptions have been noted about TIN accompanying crescentic glomerulonephritis. This diversity may be considered as only a simple histological elaboration. However, it is a significant clinical entity for guiding the treatment.
Sergey David
Lymphocytic vasculitis is one in all many skin conditions that square measure conjointly noted as body covering vasculitis. In white corpuscle vasculitis, white blood cells (lymphocytes) cause harm to blood vessels within the skin. This condition is assumed to be caused by a variety of things; however, the precise explanation for most cases isn't celebrated. This sickness will gift with a range of symptoms, reckoning on the scale, location, and severity of the affected space. In a very minority of patients, the body covering vasculitis may be a part of a lot of severe vasculitides poignant different organs within the body this can be called general vasculitis. Lymphocytic inflammation is assumed to be caused by variety of various factors, like infection, trauma, drug reaction, or AN underlying condition like inflammatory disease. As a result of this condition is rare and not nevertheless well understood, it's believed that a full list of doable causes has nevertheless to be assembled. Lymphocytic inflammation will cause variety of various symptoms. Hives, red or chromatic discoloured patches, a bump (nodule), or AN open sore (ulcer) have all been delineate as symptoms of this condition. The size, location, and severity of symptoms vary wide among affected people.
Ahmed Sharifa
Corticosteroids area unit a category of drugs that lowers inflammation within the body. They additionally cut back system activity. As a result of corticosteroids ease swelling, itching, redness, and allergies, doctors usually impose them to assist treat diseases like respiratory disease, arthritis, lupus, and allergies. Corticosteroids fit corticosteroids, a secretion naturally made by the body’s adrenal glands. The body wants corticosteroids to remain healthy. Corticosteroids could be a major player in a very big selection of processes within the body, together with metabolism, immune reaction, and stress.
Corticosteroids square measure secretion mediators created by the cortex of adrenal glands that additionally categorize into glucocorticoids, mineralocorticoids, and steroid sex hormones. They're employed in an excessiveness of conditions, ordinarily known as steroid-responsive disorders and dermatoses. Corticosteroids represent an ambiguous weapon system - vital profit with a coffee incidence of adverse effects may be expected if employed incorrect dose and for a restricted duration; but, wrong dose and/or length and unmindful withdrawal when prolonged administration will have harmful effects.
Gary S Hoffman
Cryoglobulins area unit proteins found within the blood that precipitate (clump together) within the cold and will cause inflammation and organ injury. However, these proteins also can be a gift in low levels within the blood while not inflicting any symptoms. once there are unit symptoms thanks to the cryoglobulins, the unwellness (usually a special rash) is named "cryoglobulinemia." Cryoglobulinemia may be present alone ("idiopathic") or may be related to different diseases such as Infection, significant hepatitis C infection, Blood cell abnormalities like malignant neoplastic disease and myeloma, Connective tissue malady like lupus.
Suvesh Singh, Bhavya Swarnkar*, Neetu Bhari and Akash Deep Chandra
DOI: DOI: 10.37421/2471-9544.2022.8.154
According to World Health Organization (WHO), Dolutegravir-based regimen is considered as first-line therapy for PLHIV and strongly recommended for all adults and children at the 10th International AIDS Society Conference on HIV Science (IAS 2019) held in Mexico City. Dolutegravir (integrase inhibitor) is pharmacokinetically favorable with a single daily dose, fewer drug interactions, superior potency against HIV-1, and potency against efavirenz-resistant virus. In 2020, NACO announced the phase-wise replacement of TLE regimen to TLD regimen.
Journal of Vasculitis received 83 citations as per Google Scholar report
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