Ultrasound assisted sustainable one-pot synthesis of heterocycles and bis-heterocycles via IMCRs

5^th International Conference on Organic and Inorganic Chemistry

July 12-13, 2018 | Paris, France

Roc�­o G�¡mez Monta�±o

Universidad de Guanajuato, M�©xico

Posters & Accepted Abstracts: J Chemical Sci

Abstract :

Bis-heterocycles are structural complex compounds having two linked, fused, merged or bound heterocyclic frameworks, which have more attention of synthetic community due to their potential applications in Agrochemistry, Optics, Material Science, and in Medicinal Chemistry. Particullarly, 1,5-disubstituted-tetrazoles (1,5-DS-T�s) are known as resistant bioisosters of the cis-amide bond of peptides, which are present in numerous valuable drugs like the third-generation cephalosporin antibiotic Latamoxeb. Besides, 1,5-DS-T�s are suitable precursors of a plethora of prime ligands and chelating agents. Thus, according to our ongoing program, to develop efficient and sustainable solvent and catalyst-free IMCR based methodologies towards a variety of heterocycles and bisheterocycles containing the 1,5-DS-T, we herein disclose our most recent published results. Recently, we reported the ultrasound accelerated, environmentally benign Ugi-azide based method towards the synthesis of 1,5-DS-T heterocycles under solvent and catalyst-free conditions (Green Chem., 2017, 19, 1259). In the same context, we were interested to design and develop the sustainable strategies towards the bis-heterocycles containing 1,5-DS-T with privileged molecules previously reported for their biological activities. Thus, recently, we have submitted our results of green one-pot solvent and catalyst-free IMCR/post-transformation strategy towards fused 1,5-DS-T with imidazopyridine bis-heterocycles. The developed strategies have many advantages in comparison with traditional methods reported for their synthesis.