Synthesis and anti-inflammatory activity of 7-Bromo-2–Methyl–4h–Benzo[D][1,3]– Oxazin–4–One and 3–Amino-7-Bromo-2–Methyl Quinazolin 4(3h)–One

Peter Osarodion

National Research Centre, Egypt

Posters & Accepted Abstracts: Chem Sci J

Abstract :

The current study was aimed at the synthesis and anti-microbial evaluation of quinazolinone derivatives. The condensation of Methyl-2-amino-4-bromobenzoate with acetic anhydride yielded the cyclic compound 2-methyl 7-bromo-1, 3-benzo-oxazine-4-one (1) which further produces 3-Amino-2-Methyl 7-bromo quinazolin-4(3H)-ones (2) via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of infrared, nuclear magnetic resonance (1H and 13C), gas chromatographymass spectrophotometer and elemental analysis. The synthesized compounds were screened against various strains of microorganism: Staphylococcus aureus, Bacillus species, Escherichia coli, Klebsiella pneumonia, Serratia marcescens, and Candida albicans. Compounds 1 and 2 showed significant activity against Staphylococcus aureus and Serratia marcescens with MIC ranging from 6-12 mg/mL.