Chemical Sciences Journal

ISSN: 2150-3494

Open Access

Surface Derivatization of Zirconium Phosphate Nanoplatelets: Potential Nanocarrier of Doxorubicin Anticancer Drug

4th European Chemistry Congress

May 11-13, 2017 Barcelona, Spain

Julissa Gonzalez Villegas

University of Puerto, United States

Posters & Accepted Abstracts: Chem Sci J

Abstract :

Surface modification of doxorubicin anticancer drug (DOX) intercalated zirconium phosphate (ZrP) nanoparticles ([email protected]) is proposed to improve the potential of this drug delivery system for cancer therapy. The surface of [email protected] nanoparticles was modified with an amorphous layer of Zr(IV) followed by modification with monomethyl-polyethylene glycol-monophosphate (m-PEG-PO3) to increase the [email protected] biocompatibility. 31P{1H}MAS NMR data shows a new peak at -26 ppm corresponding to the PO43- groups coordinated with Zr(IV) on the surface. m-PEG-PO3/Zr(IV)/[email protected] spectra shows no additional resonance centered at δ of -22.6 ppm generated by proton-phosphorous cross polarization indicating no partial PEG intercalation in the interlaminar space. Simulated body fluid (SBF) was used to determine the in vitro release of DOX from [email protected], Zr(IV)/[email protected] ZrP, and m-PEG-PO3/ Zr(IV)/[email protected] MTS cell viability assay reveal that m-PEG-PO3/ Zr(IV)/[email protected] exhibited a 20% increase in the toxicity comparing with free DOX when PC3 cells are exposed for 48 h. m-PEG-PO3 polymer coating of [email protected] nanoparticles promise to have a strong impact on the targeting, distribution and degradation of the nanoparticles under physiological environment that should result in a more efficient chemotherapy agent than free doxorubicin. [email protected]

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