Rossano Gimenes, Milady R Apolinario da Silva, Helena B Lopes, Gileade P Freitas and Selma Siessere
Federal University of Itajuba, Brazil
University of S�£o Paulo, Brazil
Posters & Accepted Abstracts: J Material Sci Eng
The guided bone regeneration (GBR) technique has been successfully employed in the periodontal therapy and maxillofacial surgery. On the other hand, osteoporosis is the most common metabolic disease of the bone that affects manly postmenopausal women. This disease is characterized by a reduction in bone mass, reduction of bone density and deterioration of architectural of the bone tissue. Considering the low potential for bone regeneration in host osteoroporic bone the use of allograft biomaterials to promote bone healing can be useful in the treatment of periodontal disease. The aim of this study was to evaluate the bone formation according to the GBR principle using a PVDF-TrFE/BaTiO3 placed on calvarial bone defects of osteoporotic-like rats. For this, Wistar rats weighting 250�300 g were anesthetized for the induction of osteoporosis-like conditions, by ovariectomy. Calvarial defect with 5-mm diameter was created, and sterilized membranes of P(VDF-TrFE)/BaTiO3 (TB group) and commercial membranes of e-PTFE (PTFE group) were randomly placed on the bone critical defects of all animals. Both bone volume and bone surface were not affected by the type of membrane employed (e-PTFE or P(VDF-TrFE)/BaTiO3), however bone volume and bone surface are significantly larger on the animals that received the membrane of P(VDF-TrFE)/BaTiO3 and e-PTFE (p<0.05). Hierarchical analysis of variance showed that the groups OV (osteoporotic rats) and CT (control group, non ovariectomized rats) are similar regarding the parameters bone volume and bone surface.
Email: rossano@unifei.edu.br
Journal of Material Sciences & Engineering received 3677 citations as per Google Scholar report
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