GET THE APP

Genotoxic and chronic effects of pyrethroid exposure in vector control workers and glutation s-transferase (gstm1, gstt1) genetic polymorphism
..

Environmental & Analytical Toxicology

ISSN: 2161-0525

Open Access

Genotoxic and chronic effects of pyrethroid exposure in vector control workers and glutation s-transferase (gstm1, gstt1) genetic polymorphism


5th International Conference on Environmental Toxicology and Ecological Risk Assessment

September 12-13, 2016 Phoenix, USA

Noemi Tirado Bustillos, Hansen M R, Condarco Guido, Barron J, Paz R, Cuti M and Quisberth S

University Mayor of San Andr├?┬ęs, Bolivia
Aarhus University, Denmark

Posters & Accepted Abstracts: J Environ Anal Toxicol

Abstract :

Pyrethroids are a class of insecticides in wide use globally. The acute effects of pyrethroid poisoning are well documented, but the possible chronic effects of low dose exposure are insufficiently described. The aim was to investigate the possible genetic damage, and the association between chronic low dose exposure to pyrethroids and diabetes or pre-diabetes. A cross-sectional study was performed among 122 exposed pesticide sprayers from public vector control programs in Bolivia and among 90 non-exposed controls. Pesticide exposure was determined by questionnaire. Blood samples were analyzed for comet assay, GSTM1, GSSTT1 polymorphisms and glycosylated hemoglobin A (HbA1c), a measure of glucose regulation and buccal cells sample for micronucleus. The results of the genotoxic test showed no significant difference between exposed and controls, only in cariorexis analysis (p<0.007). The prevalence of pre-diabetes or diabetes was 61.1% among vector control workers and 7.9% among controls ├ó┬?┬? raw OR 18.4 [7.8; 43.6], adjusted OR 11.8 [4.2; 33.2]. A significant positive trend was observed between cumulated pesticide exposure (total number of hours sprayed) and odds of diabetes/pre-diabetes, but only for the vector control workers who had solely used pyrethroids. Caution is warranted when interpreting the results due to the possibility of residual confounding. A healthy worker effect could explain why a dose-response relationship was only seen for the vector control workers that had only used pyrethroids. Pre-diabetes/diabetes was associated to chronic exposure to pyrethroids. Further study is warranted.

Biography :

Email: noemitirado@yahoo.com

Awards Nomination

50+ Million Readerbase

Recommended Conferences

Journal Highlights

Google Scholar citation report
Citations: 5968

Environmental & Analytical Toxicology received 5968 citations as per Google Scholar report

Environmental & Analytical Toxicology peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward