Fabrication of fluidic-based memristor sensor for dengue virus detection

Biosensors & Bioelectronics

ISSN: 2155-6210

Open Access

Fabrication of fluidic-based memristor sensor for dengue virus detection

7th Euro Biosensors and Bioelectronics Conference

July 10-11, 2017 Berlin, Germany

Asrulnizam Abd Manaf

Collaborative Microelectronic Design Excellence Center, Malaysia

Posters & Accepted Abstracts: J Biosens Bioelectron

Abstract :

Implementation of simple fluidic-based memristor sensor in bio-sensing application was presented. The sensor was fabricated using sol-gel spin coating technique and has nine well functions to increase the conjugation area to trap virus. The sensor fabricated in four sizes wells diameter of 0.5 mm, 1 mm, 1.5 mm and 2 mm. The sensors were modified with anti-dengue virus NS1 glycoprotein monoclonal antibody before applying with dengue virus 1 NS1 glycoprotein. Four concentrations of dengue viruses: 52 nM, 104 nM, 208 nM and 416 nM were prepared and applied to the modified sensor. The ability of the sensor in sensing dengue virus is measured using the off-on resistance ratio to represent the loop area. The results show that the loop area of the pinched hysteresis loop increase as the dengue virus applied to the modified sensor. The loop area also increases as the concentration of the dengue virus increases. The most obvious change in loop area observed for 416 nM dengue virus. The recorded sensitivity for the 2 mm wells diameter is 6.53??10-3 (nM)-1 which measured in fluidic-based platform. This concludes that the dengue virus produced reaction with the modified sensor and thus changes the sensors behaviors.

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