Delivery of methotrexate from nano gel hydrogel hybrid

Joint Event on 12^th International Conference and Exhibition on Materials Science and Chemistry & 30^th World Nano Conference

May 20-22, 2019 Zurich, Switzerland

Monir shalbafan, Golamreza Rezaei Behbehani and Hossein Ghasemzadeh

Imam Khomeini international University, Iran

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

The objective of this study was to develop a sustained release dosage form Methotrexate (MTX) using a natural polymeric carrier prepared in a completely aqueous environment. MTX was entrapped in calcium alginate beads prepared with sodium alginate by the ionotropic nanogel method using calcium chloride as a crosslinking agent. The drug was incorporated either into preformed calcium alginate gel beads. Fourier transform infrared (FTIR), Thermal analysis (TG/DTA), scanning electron microscope (SEM) studies on this system are discussed. The controlled release of MTX from Calcium alginate beads in buffer solution has been performed and monitored by UV-visible spectroscopy. The surface morphology of drug-loaded beads obtained from various percentages of polymer, CaCl2 and drug were studied by using a scanning electron microscope. The beads were mounted on an appropriate stub and then coated with carbon and gold (100 and 50Ã? thickness respectively) sputter module in a vacuum evaporator in an argon atmosphere. The coated samples were then observed under a scanning electron microscope operated at 15 KV. The products were characterized by Fourier transform infrared spectroscopy (FTIR), Thermal analysis (TG/DTA), and scanning electron microscope (SEM) .The controlled release of MTX from nano gel-calcium alginate beads in buffer solution was studied by changing pH, temperature, initial concentration of MTX, and the bead composition. The release of MTX was monitored by UV-visible spectroscopy. The results show that the in vitro release of MTX can be substantially affected by temperature, and nano gel content. Incorporation of nano gel into the beads could also control the rate of drug release. The release rate of MTX from the beads can be simply regulated by changing the nano gel content. It can be concluded that the modified calcium alginate beads are suitable for delivery of MTX.