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Co-administration of methotrexate and aceclofenac shows synergistic effect on rheumatoid arthritis when delivered through lipid nanocarriers
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Journal of Health Education Research & Development

ISSN: 2380-5439

Open Access

Co-administration of methotrexate and aceclofenac shows synergistic effect on rheumatoid arthritis when delivered through lipid nanocarriers


8th International Conference on Medical Education and Health Sciences

October 08-09, 2018 Osaka, Japan

Rajeev K Tyagi  Garg NK

Department of Periodontics, Augusta University, USA
Biomedical Parasitology and Nano-Immunology Lab, India
Drug Delivery Research Group, India

Scientific Tracks Abstracts: J Health Edu Res Dev

Abstract :

Methotrextae (MTX), a potent disease modifying anti-rheumatic drug (DMARDs) and aceclofenac (ACE) a wellknown NSAIDs, are widely used drugs for the treatment of rheumatoid arthritis. MTX and ACE were encapsulated in wellcharacterized lipid polymer hybrid Nanoparticles (LPHNPs) and nanostructured lipid carriers (NLCs) respectively. The efficiency of both drugs as mono- and cotherapy was assessed in lipopolysaccharide (LPS) treated and inflammation mimicked human monocytic (U937) cells. The efficiency of these drugs was confirmed by the estimation of surface inflammatory biomarkers (Immunocytochemistry) as well as transcript (RT-PCR), proteome (western blot), and histopathology. The ex-vivo results were corroborated by the results obtained in an experimentally induced (complete FreundÔ??s adjuvant supplemented with mycobacterium tuberculosis animal model) arthritis animal model. Our results present co-administration therapy (administration of MTX and ACE via LPHNPs & NLCs through intravenous and transdermal route, respectively) as an efficient therapeutic approach to treat rheumatoid arthritis. We have compared the market formulations of ACE gel and MTX administered through transdermal and subcutaneous route. Collectively, our results show the administration of developed combination drug delivery systems which may efficiently augment the enrichment of both drugs at the site of arthritis which in turn prodigiously suppresses the arthritis growth.

Biography :

Rajeev K Tyagi completed his PhD and he is currently a Professor in Department of Periodontics, College of Dental Medicine, Augusta University, Augusta, USA and a part of Biomedical Parasitology and Nano-Immunology Lab, Amity University, India

E-mail: [email protected]

[email protected]

 

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