Brief Report - (2025) Volume 16, Issue 1
Received: 01-Feb-2025, Manuscript No. CSJ-25-168661;
Editor assigned: 03-Feb-2025, Pre QC No. P-168661;
Reviewed: 15-Feb-2025, QC No. Q-168661;
Revised: 20-Feb-2025, Manuscript No. R-168661;
Published:
27-Feb-2025
, DOI: 10.37421/2160-3494.2025.16.434
Citation: Petrova, Elena. "Mesoporous Silica Carriers Improved Quercetin's Skin Delivery and Effect." Chem Sci J 16 (2025): 434.
Copyright: © 2025 Petrova E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
In the study, mesoporous silica was synthesized and used to load quercetin through adsorption techniques. Characterization of the resulting nanocarriers was performed using various analytical methods, such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Brunauerâ??Emmettâ??Teller (BET) analysis. These tools confirmed the successful incorporation of quercetin into the silica matrix and maintained the structural integrity of the nanoparticles. The porous architecture of the silica allowed for high drug loading efficiency, while its surface chemistry facilitated interactions that stabilized the quercetin molecules. In vitro release studies revealed a sustained and controlled release of quercetin from the nanocarriers, demonstrating their potential to maintain effective drug concentrations over time. This slow-release mechanism is crucial for topical applications, where prolonged exposure enhances therapeutic outcomes. Furthermore, the incorporation of quercetin into mesoporous silica was shown to protect it from oxidative degradation, ensuring that its bioactivity remained intact throughout the delivery process.
In biological assessments, the mesoporous silica-based quercetin formulation was tested for cytotoxicity and antioxidant activity using cultured skin cells. The results demonstrated that the nanocarrier system was biocompatible and non-toxic at therapeutic concentrations. Importantly, the formulation showed enhanced cellular uptake compared to free quercetin, indicating that the nanoparticles facilitated deeper and more efficient skin penetration. Antioxidant assays, such as DPPH and ABTS, confirmed that the encapsulated quercetin retained its ability to neutralize free radicals, which is essential for combating oxidative stress-related skin conditions. The study also reported reduced inflammation markers in treated cell cultures, supporting the anti-inflammatory potential of the system. Collectively, these findings suggest that mesoporous silica carriers significantly improve the pharmacological profile of quercetin for topical use, enabling better skin interaction and prolonged therapeutic action [2].
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