Influence of Infectious Diseases and the Gut-Brain Axis

Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Brief Report - (2023) Volume 17, Issue 3

Influence of Infectious Diseases and the Gut-Brain Axis

Lucas Hultgren*
*Correspondence: Lucas Hultgren, Department of Molecular Science, Arizona State University, Forest Ave Temp, USA, Email:
Department of Molecular Science, Arizona State University, Forest Ave Temp, USA

Received: 01-May-2023, Manuscript No. Jmgm-23-102722; Editor assigned: 03-May-2023, Pre QC No. P-102722; Reviewed: 15-May-2023, QC No. Q-102722; Revised: 20-May-2023, Manuscript No. R-102722; Published: 27-May-2023 , DOI: 10.37421/1747-0862.2023.17.604
Citation: Hultgren, Lucas. “Influence of Infectious Diseases and the Gut-Brain Axis.” J Mol Genet Med 17 (2023): 604.
Copyright: © 2023 Hultgren L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Infectious diseases have long been a global concern, causing significant morbidity and mortality. However, recent scientific discoveries have shed light on the intricate relationship between these diseases and the micro biome the diverse ecosystem of microorganisms that inhabit our bodies. This article explores the fascinating interplay between infectious diseases and the micro biome, highlighting how understanding this relationship can revolutionize our approach to prevention, diagnosis and treatment. The human micro biome is a complex community of bacteria, viruses, fungi and other microbes that reside primarily in our gut, but also on our skin, respiratory tract and other body surfaces. It plays a crucial role in maintaining our overall health by aiding digestion, supporting immune function and even influencing our mood. Disruptions in the delicate balance of the micro biome, known as dysbiosis, can have wide-ranging implications for our well-being.


It is essential to conduct rigorous research to ensure the safety and efficacy of interventions that involve altering the micro biome, especially when it comes to introducing genetically modified organisms into the human body. The interaction between infectious diseases and the micro biome is a dynamic and intricate process. Certain pathogens can exploit imbalances in the micro biome to establish infections. Conversely, the micro biome acts as a line of defence, competing with pathogens for resources and producing antimicrobial compounds that can inhibit their growth. Studies have shown that alterations in the composition of the micro biome can impact susceptibility to infections, including bacterial, viral and fungal diseases [1].

Understanding the role of the micro biome in infectious diseases has significant implications for prevention and treatment strategies. Maintaining a healthy and diverse micro biome through a balanced diet, regular exercise and proper hygiene practices can help prevent dysbiosis and reduce the risk of infections. Moreover, probiotics and prebiotics, which promote the growth of beneficial microbes, have shown promise in preventing and managing certain infectious diseases. Advances in sequencing technologies have enabled researchers to study the micro biome in unprecedented detail, opening new avenues for diagnosing infectious diseases. By analysing the composition and activity of the micro biome, scientists can identify specific microbial signatures associated with certain infections. This approach has the potential to revolutionize diagnostics, allowing for more accurate and timely detection of pathogens, particularly in cases where traditional methods fall short [2].

While our understanding of the micro biome's role in infectious diseases has grown significantly, many questions remain unanswered. Researchers are exploring the potential of targeted manipulation of the micro biome using genetically modified microbes or microbial therapies to combat infections. Emerging research suggests that the micro biome holds even more potential in the fight against infectious diseases. Scientists are investigating how certain beneficial bacteria can be engineered to produce antimicrobial substances, which could serve as a novel therapeutic approach. By harnessing the natural defence mechanisms of the micro biome, we may be able to develop innovative treatments that target specific pathogens while minimizing the risk of resistance. Additionally, the micro biome's influence extends beyond localized infections. Studies have revealed intriguing connections between the gut micro biome and systemic diseases, such as respiratory infections, cardiovascular diseases and even neurodegenerative disorders. These findings highlight the potential for micro biome-based interventions to have broad-ranging impacts on human health and disease [3].

However, numerous challenges lie ahead in fully harnessing the power of the micro biome. The complexity and variability of the micro biome make it challenging to establish universal guidelines for maintaining a healthy microbial balance. Furthermore, translating micro biome research into clinical practice requires collaboration among scientists, healthcare professionals and regulatory bodies. Establishing standardized protocols, developing reliable diagnostic tests and navigating regulatory frameworks are vital steps in realizing the full potential of the micro biome in infectious disease management. The relationship between infectious diseases and the micro biome is a captivating field of study that offers promising avenues for prevention, diagnosis and treatment. Understanding how the micro biome influences susceptibility to infections and exploring the therapeutic potential of micro biome-based interventions could revolutionize healthcare practices. By harnessing the power of our own microbial ecosystems, we can work towards a future where infectious diseases are better controlled and human health is bolstered by the intricate dance between our bodies and the microbial world within us [4,5].


The complex interplay between infectious diseases and the micro biome is a captivating area of research. By unravelling this relationship, scientists are paving the way for innovative strategies in the prevention, diagnosis and treatment of infectious diseases. Harnessing the power of the micro biome could lead to more effective interventions and a new era in healthcare, where our microbial allies play a pivotal role in safeguarding our well-being.


We thank the anonymous reviewers for their constructive criticisms of the manuscript. This manuscript was supported by a grant from the Americas Health Foundation (AHF), responsible for the development, organization and implementation of the consensus conference, along with independently selecting the experts to serve on the panel.

Conflict of Interest

The Author declares there is no conflict of interest associated with this manuscript.


  1. Dickson, Robert P., John R. Erb-Downward and Gary B. Huffnagle. "The role of the bacterial microbiome in lung disease." Expert Rev Respir Med 7 (2013):245-257.
  2. Google Scholar, Crossref, Indexed at

  3. Healey, Genelle R., Rinki Murphy, Louise Brough and Christine A. Butts, et al. "Interindividual variability in gut microbiota and host response to dietary interventions." Nutri rev 75 (2017): 1059-1080.
  4. Google Scholar, Crossref, Indexed at

  5. Westfall, Susan, Nikita Lomis, Imen Kahouli and Si Yuan Dia, et al. "Microbiome, probiotics and neurodegenerative diseases: Deciphering the gut brain axis." Cell Mol Life Sci 74 (2017):3769-3787.
  6. Google Scholar, Crossref, Indexed at

  7. Drengenes, Christine, Harald G. Wiker, Tharmini Kalananthan and Eli Nordeide, et al. "Laboratory contamination in airway microbiome studies." BMC microbiol 19 (2019):1-13.
  8. Google Scholar, Crossref, Indexed at

  9. Tenaillon, Olivier, David Skurnik, Bertrand Picard and Erick Denamur. "The population genetics of commensal E. coli." Nat Rev Microbiol 8 (2010):207-217.
  10. Google Scholar, Crossref, Indexed at

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