Immunopathology: Mechanisms Across a Disease Spectrum

Abdul Rahim Noor^*
*Correspondence: Abdul Rahim Noor, Department of Pathology Research, Sabah Biomedical University Kota, Kinabalu, Malaysia, Email:

Introduction

This article really digs into the complex cellular and molecular mechanisms driving rheumatoid arthritis, explaining how various immune cells and signaling pathways contribute to chronic inflammation and joint destruction. It highlights the intricate interplay that makes RA such a challenging condition to manage.[1].

This paper explores the immunopathology of solid tumors, specifically how the tumor microenvironment influences the effectiveness of immune checkpoint inhibitors. It clarifies the immune cells and molecules that either promote or hinder anti-tumor responses, shedding light on why these therapies work for some patients but not others.[2].

This review offers a comprehensive look at the immunopathology of COVID-19, outlining the immune responses that contribute to disease severity. It dissects how initial viral infection can trigger an uncontrolled inflammatory cascade, leading to lung damage and systemic complications, which is key to understanding therapeutic targets.[3].

This review delves into the intricate neuroimmunopathology of multiple sclerosis, describing how immune cells orchestrate damage within the central nervous system. It explains the roles of various immune components and their interactions with neural cells, offering clarity on the disease progression and potential therapeutic avenues.[4].

This article dissects the immunopathology behind immune-related adverse events, a growing concern with modern immunotherapies. It outlines the mechanisms by which activated immune cells mistakenly target healthy tissues, leading to various toxicities, which is crucial for developing better management strategies.[5].

This paper examines the complex immunopathology of kidney allograft rejection, highlighting the molecular pathways that orchestrate immune attack on transplanted organs. It clarifies how both innate and adaptive immune responses contribute to graft failure, offering insights into new therapeutic strategies to improve transplant outcomes.[6].

This article provides recent insights into the immunopathology of inflammatory bowel disease, explaining the dysregulated immune responses in the gut. It details how genetic predispositions, environmental factors, and an altered microbiome contribute to chronic inflammation, paving the way for more targeted therapies.[7].

This review focuses on the immunopathology of asthma, outlining the key immune cells and mediators that drive airway inflammation and hyperresponsiveness. It bridges the gap between understanding the disease's immune basis and guiding therapeutic approaches, offering a clear perspective on current and future treatments.[8].

This paper discusses the complex immunopathology of sepsis, detailing how a dysregulated immune response to infection can lead to life-threatening organ dysfunction. It covers both the hyperinflammatory and immunosuppressive phases, emphasizing the challenges in therapeutic intervention and highlighting areas for future research.[9].

This article updates our understanding of the immunopathology behind autoimmune encephalitis, a group of severe neurological disorders. It clarifies the role of autoantibodies targeting neuronal surface antigens and the subsequent immune-mediated brain inflammation, which is vital for accurate diagnosis and effective treatment.[10].

Description

The intricate field of immunopathology reveals the cellular and molecular underpinnings of various complex conditions. For example, rheumatoid arthritis is driven by complex cellular and molecular mechanisms, where specific immune cells and signaling pathways lead to chronic inflammation and joint destruction, highlighting its challenging nature [1]. Similarly, multiple sclerosis involves intricate neuroimmunopathology, with immune cells orchestrating damage within the central nervous system through interactions with neural cells, influencing disease progression and therapeutic avenues [4]. Inflammatory bowel disease also stems from dysregulated immune responses in the gut, where genetic predispositions, environmental factors, and an altered microbiome contribute to chronic inflammation, paving the way for targeted therapies [7]. Asthmaâ??s immunopathology outlines key immune cells and mediators that drive airway inflammation and hyperresponsiveness, providing a bridge between understanding the disease's immune basis and guiding therapeutic approaches [8].

Immune responses are also crucial in oncology and treatment-related issues. The immunopathology of solid tumors is explored, specifically how the tumor microenvironment impacts the effectiveness of immune checkpoint inhibitors. This clarifies the roles of immune cells and molecules that either promote or hinder anti-tumor responses, explaining variations in therapy efficacy among patients [2]. Furthermore, a growing concern with modern immunotherapies is the occurrence of immune-related adverse events. These events are rooted in immunopathology where activated immune cells mistakenly target healthy tissues, leading to various toxicities. Understanding these mechanisms is crucial for developing better management strategies for patients undergoing such treatments [5].

Beyond localized conditions, immunopathology sheds light on systemic and transplant-related challenges. Kidney allograft rejection is a complex process where molecular pathways orchestrate immune attacks on transplanted organs. Both innate and adaptive immune responses contribute significantly to graft failure, offering insights for new therapeutic strategies aimed at improving transplant outcomes [6]. Sepsis presents a life-threatening scenario where a dysregulated immune response to infection leads to organ dysfunction. This condition encompasses both hyperinflammatory and immunosuppressive phases, emphasizing the challenges in therapeutic intervention and highlighting critical areas for future research [9].

Infectious diseases, such as COVID-19, also have a profound immunopathological basis. COVID-19 immunopathology outlines immune responses contributing to disease severity, dissecting how initial viral infection can trigger an uncontrolled inflammatory cascade. This cascade often leads to lung damage and systemic complications, which is key to identifying therapeutic targets [3]. An update on the immunopathology of autoimmune encephalitis, a group of severe neurological disorders, clarifies the role of autoantibodies targeting neuronal surface antigens and subsequent immune-mediated brain inflammation. This understanding is vital for accurate diagnosis and effective treatment of these conditions [10].

Conclusion

This collection of articles offers a broad perspective on immunopathology across various diseases and conditions. It explores the complex cellular and molecular mechanisms driving rheumatoid arthritis, highlighting how immune cells and signaling pathways contribute to chronic inflammation and joint destruction. The papers also examine the immunopathology of solid tumors, focusing on the tumor microenvironment's impact on immune checkpoint inhibitors and clarifying immune responses that promote or hinder anti-tumor effects. COVID-19's immunopathology is dissected, revealing how viral infection triggers inflammatory cascades leading to lung damage and systemic complications. Neuroimmunopathology in multiple sclerosis is detailed, explaining how immune cells damage the central nervous system and interact with neural cells. Other topics include the immunopathology of immune-related adverse events from modern immunotherapies, where activated immune cells mistakenly target healthy tissues. The collection also covers kidney allograft rejection, outlining molecular pathways behind immune attacks on transplanted organs and the roles of innate and adaptive immunity in graft failure. Inflammatory bowel disease is discussed, focusing on dysregulated immune responses in the gut, influenced by genetics, environmental factors, and the microbiome. Asthma's immunopathology identifies key immune cells and mediators driving airway inflammation. Sepsis is explored, detailing how a dysregulated immune response to infection causes organ dysfunction, encompassing both hyperinflammatory and immunosuppressive phases. Finally, autoimmune encephalitis immunopathology is updated, clarifying the role of autoantibodies in immune-mediated brain inflammation.

Acknowledgement

None

Conflict of Interest

None

References

Josef SS, Daniel A, Iain BM. "Immunopathology of Rheumatoid Arthritis: Cellular and Molecular Insights".Annu Rev Med 75 (2024):271-291.

Indexed at, Google Scholar, Crossref

Jérôme G, Dario B, Stefania A. "Immunopathology of solid tumors: impact of immune checkpoint inhibitors".J Clin Invest 129 (2019):4453-4462.

Indexed at, Google Scholar, Crossref

Marcus ZT, Chee MP, Laurent R. "Immunopathology of COVID-19: A Review".Immunity 52 (2020):577-593.

Indexed at, Google Scholar, Crossref

Jason RP, Oscar CM, Weihong L. "Neuroimmunopathology of multiple sclerosis".Nat Rev Immunol 24 (2024):337-353.

Indexed at, Google Scholar, Crossref

Douglas BJ, Rohan C, Jeffrey AS. "Immunopathology of immune-related adverse events".Clin Cancer Res 26 (2020):2459-2469.

Indexed at, Google Scholar, Crossref

David S, Francesc M, Ignacio R. "Immunopathology of kidney allograft rejection: emerging molecular pathways and therapeutic targets".Nat Rev Nephrol 19 (2023):507-526.

Indexed at, Google Scholar, Crossref

Chandrima P, Sudarshan P, Tanya RPD. "The immunopathology of inflammatory bowel disease: recent insights and future directions".Dig Dis Sci 68 (2023):2801-2815.

Indexed at, Google Scholar, Crossref

Bart NL, Hamida H, Guy FJ. "Immunopathology of asthma: from diagnosis to treatment".J Allergy Clin Immunol 150 (2022):7-16.

Indexed at, Google Scholar, Crossref

Tom vdP, Frank LvdV, Luke AJO. "Immunopathology of Sepsis: Current Knowledge and Future Prospects".Immunol Rev 304 (2021):5-18.

Indexed at, Google Scholar, Crossref

Nuria G, Francesc G, Josep D. "Immunopathology of Autoimmune Encephalitis: An Update".J Autoimmun 141 (2023):102947.

Indexed at, Google Scholar, Crossref