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Uremic Cardiomyopathy Online Journals | Open Access Journals
Journal of Interventional and General Cardiology

Journal of Interventional and General Cardiology

ISSN: 2684-4591

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Uremic Cardiomyopathy Online Journals

Uremic cardiomyopathy is a typical complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular fatality in chronic renal failure. Underlying insulin resistance are defects in insulin signaling through the protein kinase, Akt. Akt acts as a nodal point in the supervision of both the metabolic and pleiotropic effects of insulin. Shortcoming among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. Here we consider the role of Akt in the development of uremic cardiomyopathy, drawing parallels from models of hypertrophic cardiac disease.The persistent growth of renal disease is of concern in many populations.1,2 Cardiovascular complications lead in all causes of mortality among patients with chronic kidney disease (CKD), accounting for approximately 50% of deaths,3 and current treatment strategies offer only modest renovation in extending life.4–6 Uremic cardiomyopathy is a classic problem in this at-risk population.

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Citations: 11

Journal of Interventional and General Cardiology received 11 citations as per Google Scholar report

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