Spontaneous Intracerebral Hemorrhage

Inflammation has been shown to play a role in animal models of intracerebral hemorrhage, but actually its role in predicting outcome in spontaneous intracerebral hemorrhage (sICH) is not clear because of the lack of evidence. In patients with sICH, the WBC count was associated with 30-day high mortality rates although, this association reversed when other confounding variables were taken in account suggesting only a role of surrogate biomarker of sICH severity. CRP concentrations appeared more effective in predicting prognosis although its predictive power is limited. Spontaneous intracerebral hemorrhage (sICH), defined as spontaneous bleeding into the brain, accounts for 10% to 20% of all strokes. Several prospective studies have been indicated that brain injury secondary to a sICH is characterized by acute local inflammation and changes in levels of inflammatory cytokines in body fluids of human patients. Elevated levels of inflammatory markers after sICH predict worse prognosis, perihematoma brain edema, early neurological deterioration, and early growth of sICH. As an elevated WBC count may be a marker of inflammation similar to CRP, we further explored the relationship among WBC count, CRP and clinical outcomes. The role of inflammation in the physiopathology of sICH is becoming increasingly well recognized.

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