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Sickle Erythrocytes | Open Access Journals
Journal of Blood & Lymph

Journal of Blood & Lymph

ISSN: 2165-7831

Open Access

Sickle Erythrocytes

Survival characteristics of human sickle erythrocytes (SS) transfused to intact chimpanzees were determined. The mean post-transfusion recovery of ^ 51 SS Crlabellated red blood cells in four chimpanzees was 30.5% ± 15.2 SD, and the survival half-life was 4.2 h ± 0.8 SD. Recovery of control human red blood cells (hemoglobin AA) in five chimpanzees was complete and their mean intravascular T 1/2 was 22.3 h. Shorter survival of sickle cell erythrocytes has also been demonstrated by transfusion of chimpanzees with mixtures of human cells such as 51Cr AA and 59Fe SS red cells, or 51Cr SS red cells and unlabelled fetal erythrocytes (cord blood). The difference in survival of AA and SS red blood cells resembles that of human recipients and was probably caused by the sickle of SS cells in the chimpanzee circulation. These primate animals could therefore be used as a model for in vivo studies of sickle cell anemia.

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