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Scholarly Journals In Drug Development | Open Access Journals
Journal of Health Education Research & Development

Journal of Health Education Research & Development

ISSN: 2380-5439

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Scholarly Journals In Drug Development

Most discovery programs seek to produce more than one candidate molecule because, many molecules do not move through the entire process because of problems with safety, kinetics, potency, intellectual property protection, or other factors. Drug developers seeking medicines for diseases, such as AD, cancer, or other difficult to treat diseases, are very eager to learn about new targets that might be the focus of a new drug discovery program. At the same time, they are often very skeptical of new findings in the scientific literature that claim to have identified a NBE or process that could be a target of interest. The investment in time and money needed to pursue a new biological target is very large so that drug developers nearly always attempt to reproduce reported findings before engaging in screening against novel targets; such efforts to reproduce even findings reported in the most reputable journals find that most, maybe even as many as 90%, cannot be reproduced. The reasons for this high failure rate are a matter of some discussion; for present purposes, it is important to note that investigators proposing that a new finding is relevant to drug discovery should expect a high level of skepticism and, even if industry investigators show interest, it is almost certain that there will be attempts to replicate the findings and explore their reproducibility with other animal models, cell lines, and physiological conditions. The range of probably safe and tolerable doses of a molecule must be determined before human testing. Toxicology studies in at least two nonhuman species are usually used to determine a projected safe dose range and to provide information about compound distribution, organ-specific toxicity, and metabolism

 

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Citations: 531

Journal of Health Education Research & Development received 531 citations as per Google Scholar report

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Correlates of Health Communication Preferences in a Multiethnic Population of Pregnant Women and Mothers of Young Children
 

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