GET THE APP
Review Articles On Pemphigus Vulgaris | Open Access Journals
Neurological Disorders

Neurological Disorders

ISSN: 2329-6895

Open Access
Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Submit Manuscript arrow_forward arrow_forward ..

Review Articles On Pemphigus Vulgaris

Pemphigus vulgaris (PV) is an autoimmune disease, normally associated with oral lesions which generally affect patients aged 40 to 60 years. PV manifests as extremely painful and persistent mouth sores. Here, we present a series of cases of PV (a man and two women aged 35 to 50). It is an attempt to emphasize its importance in diagnosis with a review of the literature on its molecular aspect.

Oral tissue biopsies were performed at the periphery of the lesions. The tissue was fixed in formalin and embedded in paraffin. The sections were stained with H and E and examined under an optical microscope. Histopathologically, the lesions presented with intraepidermal blisters, loss of intercellular attachments leading to acantholysis and an inflammatory skin infiltrate. Suprabasal epithelial clefts have been detected. Inside the slit, partially and completely detached keratinocytes (acantholytic cells) from the basal and lower layers of the prick cells were identified as single cells or clusters. In addition, lymphocytes and neutrophils were the main inflammatory cells inside the slit. In all tissue sections, the superficial parts of the connective tissue were characterized by edema, small blood vessels, a loose arrangement of collagen fibers, and inflammatory interstitial and perivascular infiltrates were evident.

Pemphigus is defined as a group of disorders the autoimmune etiology of which can be fatal and the clinical manifestations are mainly epithelial blisters affecting the skin and / or mucous surfaces, in particular the mucous membrane of the mouth, nose, conjunctiva , genitals, esophagus, pharynx and larynx. [4], [5] Although some pathogens of pemphigus are not fully understood, the high frequency of pemphigus in certain races, in particular Ashkenazi Jews and Mediterranean and South Asian origins, has been shown to be in fact linked HLA-II genes [6]. , [7] Any location of the oral mucosa can be affected; however, trauma sites such as the oral mucosa, gum and palate are particularly affected. (Dsg) 3, a protein component of desmosomes. Most PV patients have circulating IgG autoantibodies to Dsg3. These antibodies bind to Dsg3 on the membrane of epithelial cells and can cause acantholysis. [11], [12] Another desmoglein is Dsg; it is the target of the formation of autoantibodies in the leafy pemphigus. Most patients with oral lesions may be initially misdiagnosed, usually as foot and mouth disease, gingivostomatitis, erythema multiforme, erosive lichen planus, or oral thrush, and may be treated poorly for months or years. . [13] The diagram shows the mode of action of how pemphigus affects the skin and oral mucosa

High Impact List of Articles
Conference Proceedings

Relevant Topics in Neuroscience & Psychology

Awards & Nominations

Journal Highlights

Google Scholar citation report
Citations: 1343

Neurological Disorders received 1343 citations as per Google Scholar report

Citation image
Neurological Disorders peer review process verified at publons
Publon image

Indexed In

Related Links

PMC/PubMed Indexed Articles
Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine
 

Open Access Journals

arrow_upward arrow_upward