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Lyme Borreliosis | Open Access Journals
Clinical Infectious Diseases: Open Access

Clinical Infectious Diseases: Open Access

ISSN: 2684-4559

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Lyme Borreliosis

Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America and many temperate Northern Hemisphere countries. It is associated with local and systemic manifestations and has persistent post-treatment complications in some individuals. Innate and acquired immunity-related inflammation is likely to play a critical role in both the host defense against Borrelia burgdorferi and the severity of the disease. Large analytical approaches for quantification of gene expression in LB have recently arisen in order to advance the development of early, disseminated, and post-treatment biomarkers of a disease protein (proteomics) and metabolite (metabolomics). These technologies may allow the disease stage to be defined and facilitate early detection in order to improve diagnosis. They are also likely to help elucidate the underlying molecular pathways to help identify molecular targets for therapy. This article examines the findings in the field of omics relevant to LB and its potential usefulness in developing a range of biomarkers that can be used for diagnosis and detection of LB, particularly at the early stage of the disease.

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