Ting Li* and Gang Wu
High-flow oxygen inhalation, noninvasive and invasive ventilation were used for a 68-year-old female with laboratory-confirmed SARS-CoV-2 pneumonia successively. Secondary-infection, injury of liver and kidney, respiratory acidosis and coagulation disorder were revealed by laboratory findings. Two weeks after admission, chest radiograph showed pneumothorax. She died of respiratory failure four days later.
Anam Liaqat*, Muhammad Asad and Arif-Ullah Khan
Warfarin is an oral anticoagulant, which is commonly prescribed in hospital settings in various thrombotic conditions. It is known to have had a broad range of interactions with other medicinal gents widely used during clinical settings, particularly antibiotics, resulting in altered coagulation parameters and bleeding in such patients. In this study, we intend to describe two such cases that developed excessive hypoprothombinemic response due to cefoperazone and improved after substituting cefoperazone with alternative antibiotic. While there is no conclusive proof of warfarin-cefaperazone interactions, it is recommended that healthcare providers explore alternate antibiotic use in warfarin therapy patients and allow careful surveillance of the coagulation profile for all those patients receiving warfarin and antibiotics in combination with warfarin dosage modification.
Esayas Tekle*, Yonas Adisu, Sisay Teferi and Gemechu Tiruneh
DOI: 10.37421/2684-4559.2023.7.186
One of the most well-known human pathogens, Staphylococcus aureus, causes infections ranging from life-threatening conditions including sepsis, necrotizing pneumonia and, endocarditis to benign superficial skin infections. It was formerly thought to be an extracellular bacterium. However, it has been demonstrated that this pathogen can live and dwell inside cells. These features allow the pathogen to survive periods of antibiotic treatment or pressure from the immune system of the host and further enable it to start the infection once again after the environmental stress declines. Such characteristics are considered properties of Staphylococcus aureus small colony variants. Staphylococcus aureus small colony variants are often difficult to recognize due to the fact that they are endowed with unusual metabolic, physiological, and morphological characteristics that will cause difficulties for the routine diagnostic laboratory. As a result, they are associated with persistent infections.
Bayan Nurgaliyeva1,2*, Zhamal Otunbayeva1, Olga Kan3, Aizhan Moldakaryzova4, Saken Khaidarov4, Slu Izmailova5 and Gauhar Abyldayeva6
Guillain-Barré Syndrome (GBS) is an acute, progressive inflammatory polyneuropathy characterized by muscle weakness and distal sensory deficits. In the context of SARS-CoV-2 infection, GBS most commonly presents as a sensorimotor variant, frequently associated with facial paralysis and a demyelinating electrophysiological pattern. We report the case of a 47-year-old female diagnosed with stage IIb (T3, N1, M0) gastric adenocarcinoma who underwent gastrectomy followed by five cycles of adjuvant chemotherapy. During the fifth cycle, she developed SARS-CoV-2-associated pneumonia involving 30% of lung parenchyma and required hospitalization. Following recovery and discharge, the patient experienced progressive lower limb weakness and sensory disturbances. Electro Neuro Myo Graphy (ENMG) demonstrated mixed sensory and motor nerve involvement in both upper and lower extremities predominantly on the left consistent with a combined axonal-demyelinating neuropathy. This case illustrates a rare occurrence of GBS in an immunocompromised individual recovering from COVID-19. It is hypothesized that SARS-CoV-2 contributed to autoimmune activation via systemic inflammation and cytokine release, ultimately triggering GBS. Clinicians should maintain a high index of suspicion for post-infectious neuropathies such as GBS, particularly in oncology patients recovering from SARS-CoV-2 infection.
Clinical Infectious Diseases: Open Access received 1149 citations as per Google Scholar report
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