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Clinical Infectious Diseases: Open Access

Open Access

Mirian Domenech


Spain

Publications
  • Research Article
    Autolysin-Independent DNA Release in Streptococcus pneumoniae Invitro Biofilms
    Author(s): Mirian Domenech and Ernesto GarcíaMirian Domenech and Ernesto García

    Microbial biofilms provide an appropriate environment for increased genetic exchange. Extracellular DNA (eDNA) is an essential component of the extracellular matrix of microbial biofilms, but the pathway(s) responsible for DNA release are largely unknown. Autolysis (either spontaneous or phage-induced) has been proposed the major event leading to the appearance of eDNA. The ‘suicidal tendency’ of Streptococcus pneumoniae is well-known, with lysis mainly caused by the triggering of LytA, the major autolytic amidase. However, the LytC lysozyme and CbpD (a possible murein hydrolase) have also been shown involved. The present work examines the relationship between eDNA, autolysins, and the formation and main.. Read More»

    Abstract PDF

Relevant Topics

Recommended Conferences

Antibiotics: Discovery & Development

New York, USA

Infectious Diseases and Control

New York, USA

World Pathology Congress 2020

New York, USA
 
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