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Drug-susceptible Against Tuberculosis | Open Access Journals
Pharmacoeconomics: Open Access

Pharmacoeconomics: Open Access

ISSN: 2472-1042

Open Access
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Drug-susceptible Against Tuberculosis

The demand for reliable drug susceptibility testing (DST) is increasing with the expansion of surveillance for anti-tuberculosis resistance and with the need for appropriate treatment of multidrug-resistant tuberculosis, the incidence of which is gradually increasing in many parts of the world. world. However, the reliability of DST results obtained by widely used methods does not meet acceptable levels, with the exception of DST for isoniazid and rifampicin. In general, susceptibility results are highly predictable, while resistance results show low predictive values ​​when the prevalence of resistance is <10%. Poor reliability stems from a low correlation with clinical response and poor reproducibility due to the low standardization of complex and fragile test procedures. Therefore, in vitro resistance criteria for susceptibility testing should be carefully determined with representative clinical samples of Mycobacterium tuberculosis isolated from patients who have never been treated with anti-tuberculosis drugs and from patients who have failed treatment with a regimen containing the drug tested; The DST must then be carefully standardized to obtain reproducible results.

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