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Journal of Health Education Research & Development

Journal of Health Education Research & Development

ISSN: 2380-5439

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Angiotensin I (Ang-I or A(1–10)) levels were significantly superior to in non-survivors at study entry and 72 hours. ARDS survival was associated with lower concentration (OR 0.36, 95% CI 0.18–0.72, p = 0.004) but higher concentration (OR 2.24, 95% CI 1.15–4.39, p = 0.018), a biologically active metabolite of and an agonist of angiotensin II receptor type 2. Survivors had significantly higher median and ratios than the non-survivors (p = 0.001). Increased ratio suggests that angiotensin reorganize enzyme II (ACE2) activity is higher in patients who survived their ARDS insult while an increase in A(1–7)/A(1–10) ratio suggests that ACE activity is also higher in survivors. A accumulation and reduced concentration in the non-survivor group suggest that ACE2 activities may be reduced in patients succumbing to ARDS. Plasma levels of both and and their ratio may serve as useful biomarkers for prognosis in ARDS patients. RAS peptide concentrations were compared between survivors and non-survivors, and were correlated with clinical and pulmonary measures.

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Citations: 531

Journal of Health Education Research & Development received 531 citations as per Google Scholar report

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