GET THE APP

..

Journal of Anesthesiology and Pain Research

Open Access

Current Issue

Volume 4, Issue 2 (2021)

    Announcement Pages: 1 - 1

    We Cordially Invite you to Serve as a Editor for the Journal of Anaesthesiology and Pain Research

    Seth Stimberg

    First and foremost, we'd want to express our profound gratitude to every one of the Open Access Journal's editors who serve on the editorial board. The Journal of Anaesthesiology and Pain Research engaged with 18 editorial board members and it  publishes high-quality publications in the fields of anaesthesiology and pain research. An Editorial Tracking System, which is an online manuscript submission, review, and tracking device, is used for quality control in the peer-review process. Each citable manuscript must be authorised by at least two independent reviewers before being accepted by the publisher; review processing is handled by members of the Journal's editorial board or outside experts. Authors will send manuscripts and use the tracking system to track their development. As everyone is aware, reviewers play a critical role in promoting the Editors' need to maintain high standards of informative excellence in the work we distribute. We are grateful to our board members for their significant contributions to both our rigorous companion audit system and the Journal's critical advancement. Global experts in similar logical distributions are part of the Journal community. All submitted papers go through various processes to ensure uniformity in delivery. The compositions are audited using the standard companion audit procedure. Preliminary scanning is done using an endless amount of paper. After that, fitting papers are given out, along with two free references. The remarks of the arbitrators are taken into account by the Editor in Chief, who is in responsibility of making a final decision.

    Perspective Pages: 1 - 1

    Acute Respiratory Distress Syndrome: A Perspective

    Kimichi Nakamura

    Acute respiratory distress syndrome (ARDS) is a life-threatening lung disease that results in low blood oxygen levels. People who acquire acute respiratory distress syndrome can develop over several days or abruptly worsen. Shortness of breath is frequently the first symptom of acute respiratory distress syndrome. Low blood oxygen, fast breathing, and clicking, bubbling, or rattling noises in the lungs are also signs and symptoms of acute respiratory distress syndrome. Acute respiratory distress syndromes are usually sick as a result of another illness or a significant accident. Surfactant breaks degraded as fluid builds up inside the small air sacs of the lungs in acute respiratory distress syndrome can develop over several days or abruptly worsen. Shortness of breath is frequently the first symptom of ARDS. Low blood oxygen, fast breathing, and clicking, bubbling, or rattling noises in the lungs are also signs and symptoms of acute respiratory distress syndrome. Surfactant is a frothy substance that helps people breathe by keeping their lungs fully extended. These alterations make it difficult for the lungs to fill with air and transport adequate oxygen into the circulation and throughout the body. Scarring and stiffening of the lung tissue is a possibility. Acute respiratory distress syndrome can develop over several days or abruptly worsen. Shortness of breath is frequently the first symptom of acute respiratory distress syndrome can develop over several days or abruptly worsen. Shortness of breath is frequently the first symptom of acute respiratory distress syndrome.

    Opinion Pages: 1 - 1

    Hypoxemia a Critical Point to be Consider during Anaesthesia and Surgical Care

    Seth Stimberg

    Humans can only survive for a few minutes without oxygen, which is why it is such an important element for life. In order to sustain homeostasis in the body, there must be a balance between oxygen demand and delivery. The respiratory and cardiovascular systems are the two main organ systems responsible for oxygen supply in the body and maintaining homeostasis. Hypoxemia and its negative repercussions would result if any of these two functions abnormally. Hypoxemia can be caused by a variety of factors, but the most common underlying cause is a ventilation/perfusion mismatch. The current review will concentrate on the definition, aetiology, mechanisms, and treatment of hypoxemia in humans. Hypoxemia is characterised by a drop in the partial pressure of oxygen in the blood, whereas hypoxia is characterised by a reduction in tissue oxygenation. It could be caused by either a lack of oxygen delivery or a lack of oxygen use by the tissues. Hypoxia and hypoxemia do not necessarily go hand in hand. If there is a compensatory rise in haemoglobin level and cardiac output, patients can develop hypoxemia without hypoxia (CO). 

    Commentary Pages: 1 - 1

    Methylprednisolone Administration

    Khuong Lahn

    Methylprednisolone is a synthetic glucocorticoid steroid that was created to have better anti-inflammatory and mineralocorticoid activity than cortisol, the prototype glucocorticoid steroid (hydrocortisone). As a glucocorticoid or antiinflammatory medication, methylprednisolone is about four times as effective as hydrocortisone, with around 0.8 times the amount of mineralocorticoid. Methylprednisolone also has a longer action time than hydrocortisone, with a plasma half-life of 2.5 hours compared to 1.5 hours for hydrocortisone. In the current treatment of MS, methylprednisolone is particularly crucial in the acute phase of recurrence. It reduces the inflammatory cycle in a variety of ways, including dampening the inflammatory cytokine cascade, inhibiting T cell activation, decreasing immune cell extravasation into the central nervous system, facilitating apoptosis of activated immune cells, and indirectly decreasing the cytotoxic effects of nitric oxide and TNF-a. As more information about these systems becomes available, it may become possible to develop therapy regimens that are better tailored to the individual as well as the disease state. The only effective neuroprotective drug studied in controlled multicentre clinical trials is high-dose methylprednisolone, as suggested by the National Acute Spinal Cord Injury Studies (NASCIS-2 and NASCIS-3). Methylprednisolone was studied as a lipid peroxidation inhibitor, with the goal of reducing posttraumatic degenerative alterations in the damaged spinal cord. However, several researchers and physicians have questioned the usefulness of methylprednisolone for the treatment of acute traumatic SCI due to inconsistent experimental data and the relatively tiny neurological benefits shown in humans

    Commentary Pages: 1 - 1

    Dexmedetomidine: A Pain Medication

    Khuong Lahn

    Dexmedetomidine is a strong 2-adrenoceptor agonist with an affinity for the receptor that is 8 times greater than clonidine. After intravenous treatment to healthy volunteers or postsurgical patients in the intensive care unit, dexmedetomidine exerts sedative, analgesic, and anxiolytic effects. In postsurgical patients, dexmedetomidine caused a predicted haemodynamic drop (dose-dependently lower arterial blood pressure and heart rate), which coincided with lower plasma catecholamin levels. Dexmedetomidine 0.2 to 0.7 g/kg/h generated clinically effective sedation and greatly reduced analgesic requirements in postsurgical ventilated critical care unit patients in phase III clinical trials. After the assisted ventilator was turned off, there was no clinically noticeable respiratory depression. Dexmedetomidine (Precedex) is a selective a2-adrenergic receptor agonist that is a pharmacologically active dextroisomer of medetomidine. In the United States, it is approved for the sedation of mechanically ventilated adult patients in an intensive care unit, as well as non-intubated adult patients before to and/or during surgical and other procedures.

    Volume 3, Issue 1 (2020)

      Research Article Pages: 1 - 3

      Total Pain in Advanced Cancer: Are We Doing Enough?

      Shrenik Ostwal

      Share this article
      Introduction: Pain in cancer patients is multidimensional and can be contributed by physical, psychological, social and spiritual components resulting in the concept of “Total Pain”. Despite availability of a number of advanced therapeutic procedures for pain management, not all pain can be controlled with medications. Case Summary: We reported a case of a 38-year-old gentleman diagnosed with advanced carcinoma of the colon with subacute intestinal obstruction. He presented with severe complex pain not controlled with usually available modalities. Insight into physical, psycho-social and spiritual components helped to control his symptoms to some extent. Conclusion: Attention and appropriate approach to psycho-social and spiritual components along with physical symptoms (Total Pain) are highly recommended for a holistic and good end of life care. Changing goals of care should always be kept in mind while providing end of life care.
      Editorial Note Pages: 1 - 1

      Editorial Note for Journal of Anesthesiology and Pain Research

      Dr. Alena

      During the calendar year 2019, JAPRE received a total of 9 papers, out of which 4 articles (44%) were rejected in the preliminary screening due to plagiarism or being out of the format and peer review process. During 2019 around 5 articles were subjected for publication after they are accepted in the peer review process. 

      Volume 4, Issue 1 (2021)

        Opinion Pages: 1 - 2

        Anesthesiology: An Opinion

        Kimichi Nakamura*

        Anesthesiology is a medical speciality that deals with all aspects of patient care before, during, and after operation. Anesthesia, intensive care medicine, critical emergency medicine, and pain medication are all included. An anesthesiologist is a doctor who specialises in anaesthesia. The study and use of anaesthesia and anaesthetics to properly support a patient's essential functions during the perioperative phase is at the heart of the speciality. Anesthesiology has progressed from an experimental discipline in which non-specialist practitioners used novel, unproven medications and techniques in the nineteenth century to a highly refined, safe, and effective specialty of medicine today. Anesthesiologists are the largest single group of doctors in hospitals in some countries, and their responsibilities can extend far beyond providing anaesthesia care in the operating room, including prehospital emergency medicine, running intensive care units, transporting critically ill patients between facilities, and prehabilitation programmes to help patients recover faster. The practise of anaesthesia lies at the heart of anesthesiology as a discipline.

        Commentary Pages: 1 - 1

        Baclofen an Anaesthetic Therapeutic: A Commentary

        Kimichi Nakamura*

        Baclofen is a y-aminobutyric acid agonist that has been licenced for the treatment of spasticity and is widely used in the treatment of neuropathic pain. This medicine has been shown to be effective in the treatment of trigeminal neuralgia in controlled investigations. Baclofen is a gamma-aminobutyric acid agonist that has been approved for the treatment of spasticity and is commonly used in the treatment of neuropathic pain. In controlled studies, this drug has been demonstrated to be effective in the treatment of trigeminal neuralgia. The most effective use of bachfen as an adjuvant analgesic necessitates a thorough understanding of its pharmacology, side effect profile, and dose guidelines, all of which have proven to be valuable in clinical practise [1]. While baclofen was developed as a more brain penetrant form of GABA (-aminobutyric acid) for the treatment of epilepsy, its highly effective muscle relaxant qualities led to its approval as a race mate for the treatment of spasticity. Baclofen was approved by the FDA before its receptor, GABAB, was discovered and its full mechanism of action was understood.

        Perspective Pages: 1 - 1

        Complex Regional Pain Syndrome: A Brief Perspective

        Khuong Lahn

        Complex regional pain syndrome, also known as reflex sympathetic dystrophy, refers to a group of painful diseases marked by persistent regional pain that appears to be disproportionate in time or severity to any known trauma or other lesion. Changes in the somatosensory systems, which process noxious, tactile, and temperature information; the sympathetic systems, which innervate skin structures like blood vessels and sweat glands; and the somatomotor systems, which control movement, cause complex regional pain syndrome. The modifications indicate that the central nervous system representations have been updated. Patients with complex regional pain syndrome also have abnormalities in their peripheral nervous system. Pain (spontaneous pain, hyperalgesia, allodynia), active and passive movement disorders (including an increased physiological tremor), abnormal regulation of blood flow and sweating, oedema of skin and subcutaneous tissues, and trophic changes of skin, skin organs, and subcutaneous tissues are the most common symptoms. Inflammation caused by the nerves' release of certain pro inflammatory chemical signals, sensitised nerve receptors that send pain signals to the brain, dysfunction of the local blood vessels' ability to constrict and dilate appropriately, and maladaptive neuroplasticity are all clinical features of the complex regional pain syndrome. The signs and symptoms of the complicated regional pain system usually appear close to the site of the injury.

        Announcement Pages: 1 - 1

        We Cordially Invite You to Serve as a Reviewer for the Journal of Anaesthesiology and Pain Research

        Seth Stimberg

        First and foremost, we'd want to express our profound gratitude to every one of the Open Access Journal's editors who serve on the editorial board. The Journal of Anaesthesiology and Pain Research engaged with 18 editorial board members and it publishes high-quality publications in the fields of anaesthesiology and pain research. An Editorial Tracking System, which is an online manuscript submission, review, and tracking device, is used for quality control in the peer-review process. Each citable manuscript must be authorised by at least two independent reviewers before being accepted by the publisher; review processing is handled by members of the Journal's editorial board or outside experts. Authors will send manuscripts and use the tracking system to track their development. As everyone is aware, reviewers play a critical role in promoting the Editors' need to maintain high standards of informative excellence in the work we distribute. We are grateful to our board members for their significant contributions to both our rigorous companion audit system and the Journal's critical advancement. Global experts in similar logical distributions are part of the Journal community. All submitted papers go through various processes to ensure uniformity in delivery. The compositions are audited using the standard companion audit procedure. Preliminary scanning is done using an endless amount of paper.

      Relevant Topics

arrow_upward arrow_upward