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Journal of Forensic Research

ISSN: 2157-7145

Open Access

Article in Press

Volume 12, Issue 3 (2021)

    Research Article Pages: 1 - 3

    Determination of Sex by Applying Discriminant Function Analysis on the Linear Measurements of the Mental and Mandibular Foramen using OPG-A Retrospective Study

    Sukanya Desingurajan

    Disaster may be caused by natural events such as severe flooding, earthquake or volcanic eruptions.it can also be due to human activities such as mishaps involving mass transport by Land Sea, air and other causes include war, boundary disputes. Identification of individual victims by devital means is one of the most reliable methods. In case of severe disintegration visual recognition of facial features and finger prints are often impossible due to soft tissue destruction. This situation necessitates the use of the hard calcified tissue such as human dentition and jaws, pelvis and skull.

    Short Communication Pages: 1 - 2

    Data Assessment and Forensic Medical Examination of �??Sexual Integrity Crimes�?�

    Saptarshi Pal

    A forensic medical examination when committing depraved acts is carried out only in cases where there are any changes on the body of the victims, according to which it is possible to establish the fact of such actions. An examination may also be carried out in respect of material evidence. At the same time, the jurisdiction of a forensic medical expert includes the detection of traces and changes on the body of victims, as well as the mechanisms of their formation. The fact of depraved actions is established by the court and the investigating authorities.

    Volume 12, Issue 11 (2021)

      Case Report Pages: 1 - 6

      An Autopsy and Medicolegal Evaluation in a Case of Sudden Maternal Death from Pulmonary Embolism

      Pawan Mittal, Prateek Karagwal, Balraj Sharma, Meenu Gilotra, Amrita Kulhria, and Abhishek Saini, Saurabh Juneja

      Pregnancy and the postpartum period carry high risk of thromboembolic phenomenon which increases manifold postpartaly. Multiple predisposing risk factors, usually acting in combination, add up to this risk. All three of the Virchow’s triad conditions predisposing to vascular thrombosis, i.e, endothelial injury, venous stasis and hypercoagulability, are present in pregnancy. The deaths caused by pulmonary embolism may become the subject of medicolegal investigation due a sudden and unexpected fatal outcome. A thorough dissection, documentation and ancillary investigations pertaining to pulmonary emboli are important components of evaluating such fatalities. The investigation requires a dependable protocol that should include a proper evaluation of the timing of the embolus along with the residual and other thrombi, whenever discovered. Because of the pathophysiology and propagation of thrombus over a range of time period, one may see a broad histological range of thrombosis and organization. The present case pertains to the sudden death of a young female in the postpartum period who suffered a massive pulmonary embolism about 6 weeks after delivery. An extensive dissection of the lower limbs showed multiple deep venous thrombi in the calf and femoral regions while moderate to large coiled emboli were found in the pulmonary arterial vasculature. An additional histological dating of the thrombi as well as pulmonary embolus was performed that helped in elucidating the time range of their development.

      Full Length Research Paper Pages: 1 - 4

      Synthesis and Molecular Docking Study of Novel Pyridine Derivatives as Cholinesterase Inhibitors

      Mina Jamzad, Mehregan Fallah Kalamsari, Mohsen Amini, Hamid Nadri, Majid Darabi, Banafsheh Darabi

      Alzheimer’s disease (AD) which is the most commonly diagnosed cause of dementia in the elderly, is involved with a loss of presynaptic cholinergic function in the areas of the brain related to memory and learning. Preserving acetylcholine (ACh) levels by enhancement of cholinergic neurotransmission is a useful method for preventing AD occurrence and progression. In this study, a novel series of pyridine derivatives (2, 6-dimethyl-4-(2-aminophenyl)-3, 5-pyridine dicarboximide), were designed and synthesized as potent acetylcholinesterase (AChE) inhibitors. The structure of synthesized compounds was elucidated by 1HNMR, 13CNMR, FT-IR, and Mass spectroscopy techniques. Also, molecular docking studies were performed to evaluate the probable interaction between the synthesized compounds and the AChE enzyme. Based on the molecular docking study, all the proposed compounds could occupy the active sites of AChE and so may be considered as AChE inhibitors. According to the calculated binding energies, the representative compound 5c bearing para-fluorobenzyl substituent in amide moiety could be the best potent compound in this study. In-vitro and In-vivo studies are needed to confirm the In-silico results.

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Citations: 1429

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