Wan Jin Jahng
Department of Biological Sciences
Michigan Technological University, USA
He is an experienced biochemist, with expertise in techniques of proteomics as well as cell biology. He interested in understanding neurodegeneration mechanism through post-translational regulation and membrane trafficking. experiences include design, synthesis, and evaluation of enzyme inhibitors as drug candidates. Proteomics skills and knowledge of vision research were acquired in my postdoctoral training in Rando lab at Harvard Medical School. These skills and knowledge include: 1. Characterization of functional proteins in the visual cycle using proteomics; 2. Identification of biological functions for membrane proteins including lecithin retinol acyltransferase and RPE65; 3. Identification of post-translational modifications of membrane proteins; 4. Synthesis and evaluation of small molecules to treat eye diseases using mouse/rat model in vivo.
current research is focused on the use of chemical approaches to solve basic biological problems in the retina. A group of anti-apoptotic proteins, including erythropoietin, prohibiting, and PP2A are currently under the study. These proteins are involved in oxidative stress and mitochondrial signaling. Their mechanisms of action are being examined under oxidative stress in vitro and in vivo. These studies will lead to novel approaches towards the treatment and prevention of retina/RPE degeneration.