Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access

Maira Zia

Dr., Department of Surgical Sciences, Radiology, Uppsala University Hospital, Akademiska sjukhuset, Uppsala, Sweden

  • Research Article   
    [18F]Sodium-Fluoride PET/MRI Monitoring Of Hormonal Therapy Response In Breast Cancer Bone Metastases?Proof Of Concept
    Author(s): Maira Zia*, Elin Lundström, Johanna Mårtensson, Mark Lubberink, Aglaia Schiza and Anders Sundin

    RECIST 1.1 tumour size measurements on CT/MRI are the mainstay of cancer therapy monitoring. However, bone metastases are consistently difficult to evaluate for hormonal therapy response often escaping CT detection. This study aimed to assess dynamic and static [18F]sodium fluoride-([18F]NaF)-PET/MRI by combining standardized uptake value (SUV) and net influx rate (Ki) from PET with the apparent diffusion coefficient (ADC), proton density fat fraction (PDFF) and effective transverse relaxation rate (R2*) from MRI for monitoring hormonal therapy effect on bone metastases. In this prospective study, three breast cancer patients underwent a 60-minute dynamic whole-body [18F]NaF-PET/MRI before and after hormonal therapy. In PET images, pelvic and spine metastases (approx. n=10/patient) with high/intermediate uptake were delineated by.. Read More»
    DOI: 10.37421/2577-0535.2022.7.006

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