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Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access

Elin Lundström

Medical Physics, Uppsala University Hospital, Akademiska sjukhuset, Uppsala, Sweden

Publications
  • Research Article   
    [18F]Sodium-Fluoride PET/MRI Monitoring Of Hormonal Therapy Response In Breast Cancer Bone Metastases?Proof Of Concept
    Author(s): Maira Zia*, Elin Lundström, Johanna Mårtensson, Mark Lubberink, Aglaia Schiza and Anders Sundin

    RECIST 1.1 tumour size measurements on CT/MRI are the mainstay of cancer therapy monitoring. However, bone metastases are consistently difficult to evaluate for hormonal therapy response often escaping CT detection. This study aimed to assess dynamic and static [18F]sodium fluoride-([18F]NaF)-PET/MRI by combining standardized uptake value (SUV) and net influx rate (Ki) from PET with the apparent diffusion coefficient (ADC), proton density fat fraction (PDFF) and effective transverse relaxation rate (R2*) from MRI for monitoring hormonal therapy effect on bone metastases. In this prospective study, three breast cancer patients underwent a 60-minute dynamic whole-body [18F]NaF-PET/MRI before and after hormonal therapy. In PET images, pelvic and spine metastases (approx. n=10/patient) with high/intermediate uptake were delineated by.. Read More»
    DOI: 10.37421/2577-0535.2022.7.006

    Abstract HTML PDF

Google Scholar citation report
Citations: 95

Journal of Cancer Clinical Trials received 95 citations as per Google Scholar report

Journal of Cancer Clinical Trials peer review process verified at publons

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